职称:副教授
学科专业:人体解剖学
研究方向:认知、情绪及发育障碍的神经环路和突触可塑性机制
行政职务:人体解剖学实验教学中心主任
电子邮箱:tzjf_jennifer@jnu.edu.cn
个人介绍:张吉凤,女,暨南大学基础医学院人体解剖学系副教授,医学博士,硕士研究生导师。从事人体解剖学、系统解剖学、局部解剖学的教学工作及神经解剖的科研工作,研究方向为认知与发育障碍神经系统疾病的环路和突触可塑性机制。教学方面主持暨南大学教学改革项目7项,发表教学改革类文章15篇,主编教材2部,副主编教材1部,获得国家级优秀论文一等奖,获得第十届暨南大学教育教学成果奖“特等奖”(第二完成人),指导本科生获得广东省大学生创新创业项目1项,暨南大学创新创业项目3项和挑战杯项目1项。科研方面主要利用分子生物学、生物化学、分子影像学、光遗传学、电生理学及行为学等技术手段研究情绪和认知相关的神经系统疾病的环路和突触可塑性机制。主持国家自然科学基金青年项目1项,广东省自然科学基金2项、中国博士后科学基金2项,以第一和通讯作者(共同通讯)在Neuropsychopharmacology、Translational Psychiatry、Neurobiology of Disease、Molecular Neurobiology等国际期刊发表SCI论文25篇。
2016年11月-至今,暨南大学基础医学院解剖学系,讲师,副教授;
2014年10月-2016年10月,暨南大学基础医学院,博士后研究;
2012年9月-2014年9月,中山大学中山医学院,博士后研究;
2002年7月-2006年9月,华北理工大学,助教,讲师;
2009年9月-2012年7月,中山大学中山医学院分子医学专业,获医学博士学位;
2006年9月-2009年7月,暨南大学医学院人体解剖学专业,获医学硕士学位;
1997年9月-2002年7月,华北理工大学临床医学专业,获医学学士学位。
[1] Li F#, Zheng X#, Wang H, Meng L, Chen M, Hui Y, Liu D, Xie K, Zhang J*, Guo G*. Mediodorsal thalamus projection to medial prefrontal cortical mediates social defeat stress-induced depression-like behaviors. Neuropsychopharmacology. 2024. https://doi.org/10.1038/s41386-024-01829-y.
[2] Zhang W#, Zhang J#, Zhang Z#, Cha S, Li J, Chen L, Wu J, Teng J, Guo G*, Zhang J*. Effects of deSUMOylated spastin on AMPA receptor surface delivery and synaptic function are enhanced by phosphorylating at Ser210. Mol Neurobiol. 2024. doi: 10.1007/s12035-024-03935-w.
[3] Song X#, Zhang J#, Shen S#, Liu D, Zhang J, Yin W, Ye G, Wang L, Cai L, Hou H*, Qiu X*. Cardiac-adaptive conductive hydrogel patch enabling construction of mechanical-electrical anisotropic microenvironment for heart repair. Research(Wash D C). 2023, 6: 0161.
[4] Zhang H#, Yu G#, Li J#, Tu C, Hui Y, Liu D, Chen M, Zhang J*, Gong X*, Guo G*. Overexpressing lnc240 rescues learning and memory dysfunction in hepatic encephalopathy through miR-1264-5p/MEF2C axis. Mol Neurobiol. 2023, 60(4): 2277-2294.
[5] Chen M#, Jiang Y#, Li X#, Li J, Tu C, Zhang H, Gong X, Yu G*, Guo G*, Zhang J*. Enriched environment ameliorates learning and memory deficits in hepatic encephalopathy mice by restoration of the structure of dendrites and dendritic spines. Brain Res. 2023, 1804: 148264.
[6] Wang H#, Li F#, Zheng X#, Meng L, Chen M, Hui Y, Li Y, Xie K, Zhang J*, Guo G*. Social defeat drives hyperexcitation of the piriform cortex to induce learning and memory impairment but not mood-related disorders in mice. Transl Psychiatry. 2022, 12(1):380.
[7] Zhu W#, Wu F#, Li J, Meng L, Zhang W, Zhang H, Cha S, Zhang J*, Guo G*. Impaired learning and memory generated by hyperthyroidism is rescued by restoration of AMPA and NMDA receptors function. Neurobiol Dis. 2022, 171:105807.
[8] Zhang J#, Zilundu PLM#, Fu R, Zheng X, Zhou L*, Guo G*. Medical students' perceptions and performance in an online regional anatomy course during the Covid-19 pandemic. Anat Sci Educ. 2022, 15(5):928-942.
[9] Zhang J#,, Zilundu PLM#,, Zhang W#,, Yu G, Li S, Zhou L*, Guo G*. The use of a surgical boot camp combining anatomical education and surgical simulation for internship preparedness among senior medical students. BMC Med Educ. 2022, 22(1): 459.
[10] Zhu W#, Wu F#, Hu J, Wang W, Zhang J*, Guo G*. Structural investigation of the interaction mechanism between chlorogenic acid and AMPA receptor via in silico approaches. Molecules. 2022, 27(11): 3394.
[11] Zhang H#, Zhang W#, Yu G#, Li F, Hui Y, Cha S, Chen M, Zhu W, Zhang J*, Guo G*, Gong X*. Comprehensive analysis of lncRNAs, miRNAs and mRNAs in mouse hippocampus with hepatic encephalopathy. Front Genet. 2022, 13:868716.
[12] Hui Y#, Zheng X#, Zhang H#, Li F, Yu G, Li J, Zhang J*, Gong X*, Guo G*. Strategies for targeting neural circuits: how to manipulate neurons using virus vehicles. Front Neural Circuits. 2022,16: 882366.
[13] Cheng L#, Chen K#, Li J#, Wu J, Zhang J, Chen L, Guo G*, Zhang J*. Phosphorylation of CRMP2 by Cdk5 negatively regulates the surface delivery and synaptic function of AMPA receptors. Mol Neurobiol. 2022, 59(2): 762-777.
[14] Chen L#, Wang H#, Cha S#, Li J, Zhang J, Wu J, Guo G*, Zhang J*. Phosphorylation of spastin promotes the surface delivery and synaptic function of AMPA receptors. Front Cell Neurosci. 2022, 16:809934.
[15] Li S#, Zhang J#, Zhang J#, Li J, Cheng L, Chen L, Cha C*, Guo G*. Spastin interacts with CRMP2 to regulate neurite outgrowth by controlling microtubule dynamics through phosphorylation modifications. CNS Neurol Disord Drug Targets, 2021, 20(3):249-265.
[16] Zhang J#, Zilundu PLM, Zhou L, Guo G*. Supplementary regional anatomy teaching by surgeons enhances medical students mastery of anatomical knowledge and positively impacts their choice of future career. J Surg Educ. 2020, 77(5):1113-1120.
[17] Zhang J#, Li J#, Yin Y#, Li X, Jiang Y, Wang Y, Cha C*, Guo G*. Collapsin response mediator protein 2 and endophilin2 coordinate regulation of AMPA receptor GluA1 subunit recycling. Front Mol Neurosci, 2020, 13: 128.
[18] Li J#, Wu F#, Cheng L, Zhang J, Cha C, Chen L, Feng T, Zhang J*, Guo G*. A nuclear localization signal is required for the nuclear translocation of Fign and its microtubule severing function. Mol Med Rep. 2020, 21(6): 2367-2374.
[19] Zhang Z#, Zhang J#, Li J, Zhang J, Chen L, Li Y*, Guo G*. Ketamine regulates phosphorylation of CRMP2 to mediate dendritic spine plasticity. J Mol Neurosci, 2020, 70(3): 353-364.
[20] Yin Y#, Cha C#, Wu F, Li J, Li S, Zhu X, Zhang J*, Guo G*. Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β. Mol Med Rep, 2019, 19(6): 4897-4905.
[21] Zhang J#, Zhao B#, Zhu X#, Li J, Wu F, Li S, Gong X, Cha C*, Guo G*. Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines. Brain Res Bull. 2018, 139: 21-30.
[22] Zhang J#, Yin Y#, Ji Z, Cai Z, Zhao B, Li J, Tan M*, Guo G*. Endophilin2 interacts with GluA1 to mediate AMPA receptor endocytosis induced by oligomeric amyloid-β. Neural Plast, 2017, 2017:8197085.
[23] Cha C#, Zhang J#, Ji Z, Tan M, Li S, Wu F, Chen K, Gong S, Guo G*, Lin H*. CRMP4 regulates dendritic growth and maturation via the interaction with actin cytoskeleton in cultured hippocampal neurons. Brain Res Bull, 2016, 124: 286-94.
[24] Zhang J#, Tan M#, Yin Y, Ren B, Jiang N, Guo G*, Chen Y*. Distinct functions of endophilin isoforms in synaptic vesicle endocytosis. Neural Plast. 2015, 371496.
[25] Zhang J, Fan J, Tian Q, Song Z, Zhang J F, Chen Y*. 2012. Characterization of two distinct modes of endophilin in clathrin-mediated endocytosis[J]. Cell Signal, 24(11): 2043-2050.
1.《系统解剖生理学》. 华中科技大学出版社,2023年.(主编)
2. 《人体解剖生理学》. 北京大学医学出版社,2020年(主编)
3. 《系统解剖学》.北京大学医学出版社,2018年(副主编)
4. 《Grant解剖学操作指南》(第17版). 北京科学技术出版社,2022年 (参译)
1. 2020 年第十届暨南大学教育教学成果奖“特等奖”(第二完成人)
2. 2019年9月荣获基础医学院2019年新任教师教学设计竞赛二等奖
3. 2019年8月,外科医生走进局部解剖学课堂有助于知识掌握和未来职业规划, 获得全国高等院校第五届实验教学及实验技术工作者优秀论文一等奖(第一作者)
4. 2018年5月荣获暨南大学基础医学院2018年“德仁杯”教学竞赛二等奖
5. 2016年12月荣获暨南大学第四届本科课程新任教师教学竞赛自然科学组二等奖
广东省解剖学会第十四届理事会 理事
中国研究型医院学会神经再生与修复专业委员会 青年委员
中国研究型医院学会神经再生与修复专业委员会周围神经损伤与修复学组 委员
中国解剖学会第十七届理事会虚拟现实分会 委员