个人简介

职称：副教授

学科专业：生理学

研究方向：神经精神疾病发病机制研究

电子邮箱：jiczhang825@qq.com

个人简介：医学博士，暨南大学基础医学院生理系副教授。2013年毕业于日本千葉大学（Chiba University），获医学博士学位。分别曾在日本千葉大学，美国Emory大学，东京医科齿科大学从事博士后及助理教授研究工作。主要研究领域：抑郁症，阿尔茨海默病及帕金森病的发病机制研究。近年来在Biology Psychiatry、PNAS、Mol Psychiatry、Transl Psychiatry 等著名国际主流学术期刊发表SCI论文50余篇。

学习科研经历

2019.07-至今，暨南大学基础医学院生理学系，副教授

2017.11-2019.06，东京医科齿科大学神经病态学系，助理教授（日本）

2016.11-2017.09，埃默里大学病理和实验医学系，博士后（美国）

2013.10-2016.10，千葉大学社会精神保健教育研究中心，助理教授（日本）

2010.04-2013.09，千葉大学社会精神保健教育研究中心，博士（日本）

2006.02-2008.02，西安交通大学临床医学，学士

2000.09-2003.07，西安医学院，临床医学

主要论文

1. Yao W#, Cao QQ#, Luo SL#, He LJ, Yang C, Chen JX, Qi Q*, Hashimoto K*, and Zhang JC* Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine, Molecular Psychiatry. 2021, in press. (IF: 15.992；JCR 1区；通讯作者)

2. Tang R#, Cao QQ#, Hu SW#, He LJ, Du PF, Chen G, Fu R, Xiao F, Sun YR*, Zhang JC* and Qi Q*. Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription, Acta Pharmacologica Sinica. 2021, in press. (IF: 6.150；JCR 1区；通讯作者)

3. Yao W#, Lin S#, Su J, Cao QQ, Chen YY, Chen JX, Zhang ZT, Hashimoto K*, Qi Q* and Zhang JC*. Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents, Transl Psychiatry. 2021, 11: 140. (IF: 6.222；JCR 1区；通讯作者)

4. Zhang JC, Yao W, Dong C, Han M, Shirayama Y, and Hashimoto K. Keap1–Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress. Eur Arch Psychiatry Clin Neurosci. 2018, 268 (8): 865-870. (IF: 3.569)

5. Zhang JC, Yao W, Qu YG, Nakamura M, Dong C, Yang C, Ren Q, Ma M, Han M, Shirayama Y, Hayashi-Takagi A, and Hashimoto K. Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype. Sci Rep, 2017, 7: 7133. (IF: 4.259)

6. Zhang JC, Yao W, Dong C, Yang C, Ren Q, Ma M, Hashimoto K. Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut–microbiota–brain axis. Transl Psychiatry. 2017, 7, e1138. (IF: 5.182)

7. Zhang JC, Yao W, Dong C, Yang C Y, Ren Q, Ma M, Han M, Wu J, Ushida Y, Suganuma H, Hashimoto K. Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation. J Nutr Biochem 2016, 39: 134–144. (IF: 4.490)

8. Zhang JC, Yao W, Ren Q, Yang C, Dong C, Ma M, Wu J & Hashimoto K. Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens. Sci Rep, 2016, 6: 36705. (IF: 4.259)

9. Zhang JC, Yao W, Hashimoto K. Brain-derived neurotrophic factor (BDNF) - TrkB signaling in inflammation-related depression and potential therapeutic targets. Current Neuropharmacology 2016, 14(7): 721-31. (IF: 4.068)

10. Zhang JC, Yao W, Dong C, Yang C, Ren Q, Ma M, Han M, Hashimoto K. Comparison of ketamine, 7,8-dihydroxyflavone and ANA-12 antidepressant effects in the social defeat stress model of depression. Psychopharmacology (Berl) 2015, 232(23): 4325-4335. (IF: 3.540) 

11. Zhang JC, Wu J, Fujita Y, Yao W, Ren Q, Yang C, Li SX, Shirayama Y, Hashimoto K. Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation. Int J Neuropsychopharmacol 2015, 18(4): pyu077. (IF: 4.333)

获奖及荣誉

1. 2021年度基础医学与公共卫生学院“优秀科研工作者”