个人简介

职称：副研究员

学科专业：药理学

研究方向：中药及天然产物活性成分发现及其活性评价和作用机制研究

电子邮箱：ybzhang99@126.com

个人简介：主要研究方向中药活性成分发现及其活性评价和作用机制研究。对中药苦豆子、苦参等十余种中草药进行了研究，共发现了300多个化合物，其中3个化合物被本领域权威期刊《Natural Product Reports》(IF: 11.876)评为热点分子，并对多个药理活性显著的化合物的作用机制进行了研究。主持国家自然科学基金-青年基金、博士后科学基金面上项目(一等资助)、博士后科学基金特别资助项目各1项；以第一/通讯作者身份在《Organic Letters》、《Journal of Natural Products》等杂志发表SCI论文19篇；获得过2019年广东省100位博士博士后创新人物称号。

学习科研经历

2019.10至今，暨南大学基础医学院药理学系，副研究员

2017.08-2019.10，暨南大学中西医结合博士后流动站，博士后

主要论文

1. Yu-Bo Zhang, Li Yang, Ding Luo, Neng-Hua Chen, Zhong-Nan Wu, Wen-Cai Ye, Yao-Lan Li, Guo-Cai Wang. Sophalines E–I, five quinolizidine-based alkaloids with antiviral activities against the hepatitis B virus from the seeds of Sophora alopecuroides. Organic Letters, 2018, 20(18), 5942-5946. (第一作者, A1, 1区)

2. Yu-Bo Zhang, Xiao-Li Zhang, Neng-Hua Chen, Zhong-Nan Wu, Wen-Cai Ye, Yao-Lan Li, and Guo-Cai Wang. Four matrine-based alkaloids with antiviral activities against HBV from the seeds of Sophora alopecuroides. Organic Letters, 2017, 19(2), 424-427. (第一作者, A1, 1区)

3. Yu-Bo Zhang, Li-Qin Zhan, Guo-Qiang Li, Feng Wang, Ying Wang, Yao-Lan Li, Wen-Cai Ye, Guo-Cai Wang. Dimeric matrine-type alkaloids from the roots of Sophora flavescens and their anti-hepatitis B virus activities. The Journal of Organic Chemistry, 2016, 81(15), 6273-6280. (第一作者, A1, 2区)

4. Guo-Qiang Li,# Yu-Bo Zhang,# Peng Wu,# Neng-Hua Chen, Zhong-Nan Wu, Li Yang, Rui-Xia Qiu, Guo-Cai Wang, Yao-Lan Li. New phloroglucinol derivatives from the fruit tree Syzygium jambos and their cytotoxic and antioxidant activities. Journal of Agricultural and Food Chemistry, 2015, 63(47), 10257-10262. (共同第一作者, A1, 1区)

5. Neng-Hua Chen,# Yu-Bo Zhang,# Xiao-Jun Huang, Lin Jiang, Si-Qi Jiang, Guo-Qiang Li, Yao-Lan Li, Guo-Cai Wang. Drychampones A-C: Three meroterpenoids from Dryopteris championii. The Journal of Organic Chemistry, 2016, 81(19), 9443-9448. (共同第一作者, A1, 2区)

6. Yu-Bo Zhang, Ding Luo, Li Yang, Wen Cheng, Li-Jun He, Guang-Kai Kuang, Man-Mei Li, Yao-Lan Li, Guo-Cai Wang. Matrine-type alkaloids from the roots of Sophora flavescens and their antiviral activities against the hepatitis B virus. Journal of Natural Products, 2018, 81(10), 2259-2265. (第一作者, A1, 2区)

7. Chun-Lin Fan,# Yu-Bo Zhang,# Ye Chen,# Pei Xie, Guo-Cai Wang, Hai-Yan Tian, Yao-Lan Li, Xiao-Jun Huang, Xiao-Qi Zhang, Zhi-Yong Li, Jun-Shan Liu,* Wen-Cai Ye, Wei-Min Chen*. Alopecuroides A−E, matrine-type alkaloid dimers from the aerial parts of Sophora alopecuroides. Journal of Natural Products, 2019, 81(10), 2259-2265. (共同第一作者, A1, 2区)

8. Yu-Bo Zhang,# Wen Li,# Lin Jiang, Li Yang, Neng-Hua Chen, Zhong-Nan Wu, Yao-Lan Li, Guo-Cai Wang. Cytotoxic and anti-inflammatory active phloroglucinol derivatives from Rhodomyrtus tomentos. Phytochemistry, 2018, 153, 111-119. (共同第一作者, A2, 3区) 

9. Ding Luo, Si Xiong, Qing-Guo Li, Lin Jiang, Qian-Wen Niu, Li-Jun He, Yao-Lan Li, Yu-Bo Zhang,* Guo-Cai Wang.* Terpenoids from the stems of Celastrus hindsii and their anti-RSV activities. Fitoterapia, 2018, 130, 118-124. (共同通讯作者, A2, 3区)

10. Yu-Bo Zhang,# Peng Wu,# Xiao-Li Zhang, Chao Xia, Guo-Qiang Li, Wen-Cai Ye, Guo-Cai Wang, Yao-Lan Li. Phenolic compounds from the flowers of Bombax malabaricum and their antioxidant and antiviral activities. Molecules, 2015, 20(11), 19947-19957. (共同第一作者, A2, 3区)

11. Li Yang,# Yu-Bo Zhang,# Li-Feng Chen, Neng-Hua Chen, Zhong-Nan Wu, Si-Qi Jiang, Lin Jiang, Guo-Qiang Li, Yao-Lan Li, Guo-Cai Wang. New labdane diterpenoids from Croton laui and their anti-inflammatory activities. Bioorganic & Medicinal Chemistry Letters, 2016, 26(19), 4687-4691. (共同第一作者, A2, 3区)

12. Chun Wu, Li-Jun He, Xue Yi, Juan Qin, Yao-Lan Li, Yu-Bo Zhang,* Guo-Cai Wang*. Three new alkaloids from the roots of Sophora tonkinensis. Journal of Natural Medicines, 2019, 73(3): 667-671. (共同通讯作者, A2, 4区)

13. Yu-Bo Zhang, Wen Li, Ze-Ming Zhang, Neng-Hua Chen, Xiang-Qiang Zhang, Jian-Wei Jiang, Guo-Cai Wang, Yao-Lan Li. Two new triterpenoids from the roots of Rhodomyrtus tomentosa. Chemistry Letters, 2016, 45(3), 368-370. (第一作者, A2, 4区)

14. Bai-Lian Liu, Qiu-Ping Liang, Ding Luo, Peng Wu, Guo-Cai Wang, Dong-Lin Xu, Yu-Bo Zhang,* Guang-Xiong Zhou*. Three new triterpenoids from the bark and twigs of Schima crenata. Chemistry Letters, 2019, 48(7): 634-636. (共同通讯作者, A2, 4区)

15. Zhong-Nan Wu,# Yu-Bo Zhang,# Neng-Hua Chen, Li Yang, Lin Jiang, Si-Qi Jiang, Guo-Qiang Li, Yao-Lan Li, and Guo-Cai Wang. Three new eudesmanolides from the herbs of Wedelia prostrate. Chemistry Letters, 2016, 45(10), 1150-1152. (共同第一作者, A2, 4区)

16. Ding Luo,# Yu-Bo Zhang,# Jie Huang, Li-Feng Chen, Li-Jun He, Guang-Kai Kuang, Juan Qin, Qing-Guo Li, Guo-Cai Wang, Yao-Lan Li. One New Sesquiterpene from the Leaves of Rhodomyrtus tomentosa. Chemistry Letters, 2019, 48(1), 55-57. (共同第一作者, A2, 4区)

17. Yuan-Lin Zhong,# Yu-Bo Zhang,# Ding Luo, Qian-Wen Niu, Juan Qin, Li-Jun He, Yao-Lan Li, Guo-Cai Wang. Two new compounds from Wedelia chinensis and their anti-inflammatory activities. ChemistrySelect, 2018, 3(12), 3459-3462. (共同第一作者, A2, 4区)

18. Yu-Bo Zhang,# Kar-Ho Lam,# Li-Feng Chen, Hei Wan, Guo-Cai Wang, Kai-Fai Lee, Chun-Wang Yip, Kwun-Hung Liu, Pak-Heng Leung, Hai-Yong Chan, Yi-Gang Shi, Jia Zhao, Li-Xing Lao, Yao-Lan Li, Yan-Bo Zhang,* Wei Meng*. Chemical constituents from the thorns of Gleditsia sinensis and their cytotoxic activities. Journal of Asian Natural Products Research, 2020. https://doi.org/10.1080/10286020.2020.1731799 (第一作者, A2, 4区)

19. Yu-Bo Zhang, Huan Liu, Cun-Ya Zhu, Mao-Xin Zhang, Yao-Lan Li, Bing Ling, Guo-Cai Wang. Cucurbitane-type triterpenoids from the leaves of Momordica charantia. Journal of Asian Natural Products Research, 2014, 16(4), 358-63. (第一作者, A2, 4区)

获奖及荣誉

1、广东省100位博士博士后创新人物，2019

学术兼职

广东省抗炎免疫药理学会会员、《Planta Medica》、《Natural Product Research》杂志审稿专家