职称:副教授
行政职务:药理系主任
学科专业:药理学
研究方向:
神经药理学
电子邮箱:xiaofei@jnu.edu.cn
个人简介:
肖飞,医学博士,副教授,硕士生导师,暨南大学医学院药理学系主任。从事药理学研究,研究方向为神经退行疾病发病机制与促神经再生药物研究。指导本科生创新训练项目5项,主持国家自然基金课题1项,广东省自然基金课题2项,广东省医学科学技术研究基金1项,广州市科技计划项目1项。参与阿尔茨海默病相关课题7项。已发表相关论文32篇,SCI收录24篇(一作或通迅作者15篇)。申请专利4项,其中授权3项。获广东省科学技术奖三等奖1项,毕业博士论文被暨南大学授予优秀博士研究生论文。目前任广东省药理学会理事,广东省药理学会神经药理学专业委员会委员,广东省药理学会药物毒理专业委员会委员,广东省神经科学学会理事。广东省自然基金评审专家,《中华神经医学》杂志审稿专家。
1995.09-2000.07,武汉大学/医学院临床医学专业,获医学学士学位;
2000.09-2003.07,暨南大学/药学院药理学专业,获医学硕士学位;
2007.09-2010.07,暨南大学/医学院病理学与病理生理学专业,获医学博士学位;
2003.07-2005.10,暨南大学药学院神经药理研究室, 研究实习员;
2005.11-2012.10,暨南大学医学院病理生理教研室, 助理研究员;
2012.10-至今,暨南大学医学院药理学系主任,机能中心主任,硕士生导师,副教授。
1) Zhang Z, Wang Z, Ling Z, Li Y, Pan J, Gao Q, Zhang J, Yan L, Zhang Z, Li J, Xiao F(通讯作者). A screened PirB antagonist peptide antagonizes Abeta42-mediated inhibition of neurite outgrowth in vitro. Appl Microbiol Biotechnol. 2021 Jun 1. doi: 10.1007/s00253-021-11363-2.
2) Xie QQ, Feng X, Huang Y, Fang N, Yi H, Wang ZJ, Cao Q, Lou GF, Pan JP, Hu Y, Li, F. C,Zheng, Q,Xiao F(通讯作者). Nogo66 promotes beta-amyloid protein secretion via NgR/ROCKdependent BACE1 activation. Mol Med Rep. 2021;23(3).
3) Huang YY, Fang N, Luo HR, Gao F, Zou Y, Zhou LL, Zeng QP, Fang SS, Xiao F(通讯作者), Zheng Q: RP1, a RAGE antagonist peptide, can improve memory impairment and reduce Abeta plaque load in the APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology 2020, 180:108304.
4) Wang JH, Chen KQ, Jiang JX, Li HY, Pan JP, Su JY, Wang L, Hu Y, Mi XN, Xin YR, Xiao F(通讯作者), Luo HM: Excretion, Metabolism and Cytochrome P450 Inhibition of Methyl 3,4-Dihydroxybenzoate (MDHB): A Potential Candidate to Treat Neurodegenerative Diseases. Eur J Drug Metab Ph 2020, 45(1):51-69.
5) Xin YR, Jiang JX, Hu Y, Pan JP, Mi XN, Gao Q, Xiao F(通讯作者), Zhang W, Luo HM: The Immune System Drives Synapse Loss During Lipopolysaccharide-Induced Learning and Memory Impairment in Mice. Front Aging Neurosci 2019, 11:279.
6) Pan JP, Hu Y, Wang JH, Xin YR, Jiang JX, Chen KQ, Yang CY, Gao Q, Xiao F(通讯作者), Yan L et al: Methyl 3,4-Dihydroxybenzoate Induces Neural Stem Cells to Differentiate Into Cholinergic Neurons in vitro. Front Cell Neurosci 2018, 12:478.
7) Rendong Hu,Qiaoyu Cao ,Zhongqing Sun, Jinying Chen , Xiao F(通讯作者), Qing Zheng:A novel method of neural differentiation of PC12 cells by using Opti-MEM as a basic induction medium,International Journal of Molecular Medicine. 2018 Jan;41(1):195-201.
8) Yu Li , Zhongqing Sun, Qiaoyu Cao, Meiwan Chen, Huanmin Luo, Xi Lin, Xiao F(通讯作者):A role of amyloid β-protein receptors in mediating synaptic plasticity, Biomedical Reports. 2017 Apr;6(4):379-386.
9) Huimin Li, Yinglu Shi, Di Wen, Huanmin Luo, Xi Lin, Xiao F(通讯作者): A novel effective chemical Hemin for the treatment of acute carbon monoxide poisoning in mice. Experimental and Therapeutic Medicine. 2017 Nov;14(5):5186-5192..
10) Cai Y, Sun Z, Fang X, Fang X, Xiao F(通讯作者), Wang Y, Chen M: Synthesis, characterization and anti-cancer activity of Pluronic F68-curcumin conjugate micelles. Drug delivery 2015:1-9.
11) Dai XY, Sun ZQ, Liang R, Li Y, Luo HM, Huang YD, Chen MW, Su ZJ, Xiao F(通讯作者): Recombinant Nogo-66 via soluble expression with SUMO fusion in Escherichia coli inhibits neurite outgrowth in vitro. Appl Microbiol Biot 2015, 99(14):5997-6007.
12) Sun ZQ, Dai XY, Li Y, Jiang SW, Lou GF, Cao QY, Hu RD, Huang YD, Su ZJ, Chen MW, Sun J, Xiao F(通讯作者): A novel Nogo-66 receptor antagonist peptide promotes neurite regeneration in vitro. Mol Cell Neurosci 2016, 71:80-91.
13) Xiao F(第一作者), Li XG, Zhang XY, Hou JD, Lin LF, Gao Q, Luo HM: Combined administration of D-galactose and aluminium induces Alzheimer-like lesions in brain. Neurosci Bull 2011, 27(3):143-155.
14) Xiao F(第一作者), Lin LF, Cheng X, Gao Q, Luo HM: Nogo-66 receptor activation inhibits neurite outgrowth and increases beta-amyloid protein secretion of cortical neurons. Mol Med Rep 2012, 5(3):619-624.
15) Xu YQ, Sun ZQ, Wang YT, Xiao F(通讯作者), Chen MW: Function of Nogo-A/Nogo-A Receptor in Alzheimer's Disease. Cns Neurosci Ther 2015, 21(6):479-485.
1. 盛树力主编《老年性痴呆及相关疾病》,科技文献出版社,2006年4月出版。(参与编写第十五章老年性痴呆的动物模型及评价)
2. 罗焕敏主编《神经药理学基础》,暨南大学出版社,2011年6月出版。(参与编写第十二章 抗脑衰老及抗老年痴呆药物)
1. 2007年荣获广东省科学技术奖三等奖。(罗焕敏,肖飞,李晓光. 抗老年痴呆药物筛选系统的建立和应用. No. B17-0-3-01)
1. 中华神经医学审稿专家;
2. 广东省药理学会理事;
3. 广东省药理学会神经药理学专业委员会委员;
4. 广东省药理学会药物毒理专业委员会委员;
5. 广东省神经科学学会理事.