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职称：中级
学科专业：医学细胞生物学
研究方向：糖胺聚糖的结构和功能研究
行政职务：无
电子邮箱：nwu5999@jnu.edu.cn
个人介绍：吴念博士，2011至2014年硕士就读于浙江大学食品安全专业，师从叶兴乾教授和陈士国教授。2014年4月，获得中国国家留学基金委的学费和生活费全额资助（全国前5%），远赴全球排名前十的英国帝国理工学院（Imperial College London）攻读博士学位。所在的Glycosciences Laboratory在糖生物和化学领域享有较高的声望，导师为英国医学科学院院士Ten Feizi教授和Wengang Chai高级研究员。2017年获得英国Henry Lester Trust奖学金，并于次年1月获得博士学位。2019年3月，入职暨南大学。吴念博士长期从事糖胺聚糖的结构和功能研究，主持6项国家级、省部级以及校级基金，近年来分别在Journal of Agricultural and Food Chemistry，Molecular & Cellular Proteomics，Carbohydrate Polymers等杂志发表SCI论文十余篇，授权发明专利一项。
2014-10至2018-01 Imperial College London，糖生物学专业，博士
导师: Ten Feizi，Wengang Chai
2011-09至2014-03 浙江大学，食品安全专业，硕士
导师：叶兴乾，陈士国
2006-09至2010-06 武汉纺织大学，轻化工程专业，学士
2019-03至今 暨南大学，基础医学与公共卫生学院，组织学与胚胎学系，讲师
1. Y Chen#, Y Zhuo#, S Wan#, Y Li, S Chen, G Wang*, N Wu*. Fucosylated chondroitin sulfate alleviates colonic barrier dysfunction in Parkinson’s disease via epithelial cell modulation and microecology restoration[J]. Journal of Functional Foods. 2025, 127:106753, DOI: 10.1016/j.jff.2025.106753.
2. Y Liu#, X Liu#, Q Ye#, Y Wang#, J Zhang, S Lin, G Wang, X Yang, J Zhang*, S Chen*, N Wu*. Fucosylated chondroitin sulfate against parkinson’s disease through inhibiting inflammation induced by gut dysbiosis. Journal of Agricultural and Food Chemistry. 2022, 70, 13676-13691.
3. N Wu#, Y Li#, X He#, J Lin#, D Long, X Cheng, B Brand-Saberi, G Wang*, X Yang*. Retinoic acid signaling plays a crucial role in excessive caffeine intake-disturbed apoptosis and differentiation of myogenic progenitors. Frontiers in Cell and Developmental Biology. 2021, (9),1-15.
4. F Gyapon-Quast, E de Jorge, T Malik, N Wu, J Yu, W Chai, T Feizi, Yan Liu and Matthew C. Pickering. Defining the Glycosaminoglycan Interactions of Complement Factor H-Related Protein 5. The Journal of Immunology. 2021, 207, 534-541.
5. J Wu, M Wu, H Zhang, X Zhan, N Wu. An oligomannuronic acid-sialic acid conjugate capable of inhibiting Aβ42 aggregation and alleviating the inflammatory response of BV-2 microglia. International Journal of Molecular Sciences. 2021, 22(22), 12338.
6. N McAllister, Y Liu, L Silva, A Lentscher, W Chai, N Wu, K Griswold, K Raghunathan, L Vang, J Alexander, K Warfield, M Diamond, T Feizi, L Silva, T Dermody. Chikungunya Virus Strains from Each Genetic Clade Bind Sulfated Glycosaminoglycans as Attachment Factors. Journal of Virology. 2020, 94(24), e01500-20.
7. N Wu, L Silva, Y Liu, Y Zhang, C Gao, F Zhang, F Li, Y Peng, R Linhardt, T Kawasaki, B Mulloy, W Chai, T Feizi. Glycan markers of human stem cells assigned with beam search arrays. Molecular & Cellular Proteomics. 2019, 18(10), 1981-2002.
8. N Chandra, Y Liu, J Liu, L Frangsmyr, N Wu, L Silva, M Lindstrom, W Chai, F Domellof, T Feizi, and N Arnberg. Sulfated glycosaminoglycans as viral decoy receptors for human adenovirus type 37. Viruses. 2019, 11(3), 247.
9. N Wu#, Y Zhang#, X Ye, Y Hu, T Ding, and S Chen. Sulfation pattern of fucose branches affects the anti-hyperlipidemic activities of fucosylated chondroitin sulfate. Carbohydrate Polymers. 2016, 147, 1-7.
10. B Mulloy, N Wu, F Gyapon-Quast, L Lin, F Zhang, M Pickering, R Linhardt, T Feizi, W Chai. Abnormally high content of free glucosamine residues identified in a preparation of commercially available porcine intestinal heparan sulfate. Analytical Chemistry. 2016, 88(13), 6648-6652.
11. N Wu, S Chen, X Ye, G Li, L Yin, and C Xue. Identification of fucans from four species of sea cucumber by high temperature 1H NMR. Journal of Ocean University of China. 2014, 13(5), 871-876.
12. R Gao, N Wu, Y Li, and S Chen. Structures and anticoagulant activities of the partial mild acidic hydrolysis products of the fucosylated chondroitin sulfate from sea cucumber Pearsonothuria graeffei. Journal of Carbohydrate Chemistry. 2014, 33, 471-488.
13. X Guo, X Ye, Y Sun, D Wu, N Wu, Y Hu, and S Chen. Ultrasound effects on the degradation kinetics, structure, and antioxidant activity of sea cucumber fucoidan. Journal of Agricultural and Food Chemistry. 2014, 62, 1088-1095.
14. N Wu, X Ye, X Guo, N Liao, X Yin, Y Hu, Y Sun, D Liu, and S Chen. Depolymerization of fucosylated chondroitin sulfate from sea cucumber, Pearsonothuria graeffei, via 60Co irradiation. Carbohydrate Polymers. 2013, 93, 604-614.
15. S Chen, G Li, N Wu, X Guo, N Liao, X Ye, D Liu, C Xue, and W Chai. Sulfation pattern of the fucose branch is important for the anticoagulant and antithrombotic activities of fucosylated chondroitin sulfates. Biochimica et Biophysica Acta. 2013, 1830 (4), 3054-3066.
16. N Liao, S Chen, X Ye, J Zhong, N Wu, S Dong, B Yang, and D Liu. Antioxidant and anti-tumor activity of a polysaccharide from freshwater clam, Corbicula fluminea. Food & Function. 2013, 4, 539-548.
2024，“暨南英才计划”暨南杰青第二层次
2021，指导本科生秦雨婵等获得“全国大学生基础医学创新研究暨实验设计大赛”南部赛区优秀奖
2020，广东省本科高校在线教学优秀案例（排名第三）；广东省一流本科课程（排名第五）
2017，英国“Henry Lester Trust”奖学金
2014-2017，中国国家留学基金委学费和生活费全额资助
2014，硕士研究生国家奖学金；浙江大学优秀毕业生
Frontiers in Cell and Developmental Biology（Morphogenesis and Patterning）编委