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职称：教授（绿色通道聘）
学科专业：病理生理学
研究方向：脓毒症发病机制、天然免疫调控与疾病
行政职务：
电子邮箱：dmyang@jnu.edu.cn
个人介绍：杨多猛，医学博士，暨南大学基础医学与公共卫生学院高层次引进人才，教授，博士研究生导师，主要研究脓毒症发病机制，以及天然免疫在感染、自身免疫性疾病及衰老等发生过程中的调控机制。2019-2024年于美国University of Connecticut Health Center 进行博士后研究，发现泛素相关UBXNs家族蛋白分子对脓毒症中非经典炎症小体激活以及病毒感染诱发天然免疫反应的调控作用及机制；发现RIG-I家族受体（RLRs）在抗病毒天然免疫反应中多种新的调控模式。近年来，在国际知名SCI期刊发表论文近30篇，其中第一及通讯作者论文10篇，包括Nature Immunology、Nature Communications、Military Medical Research、EBioMedicine、Communications Biology和iScience等；获得国家发明专利1项。获批美国UCONN-COVID-RSF (Rapid Start Funding)-Award研究基金（Co-PI），参与美国NIH基金支持的多项研究工作；参与国家自然科学基金面上项目、联合基金项目等。担任“中国科技期刊卓越行动计划英文领军期刊” Military Medical Research科学编辑；担任Nature Communications, Emerging Microbes & Infections, Free Radical Biology and Medicine, Burns & Trauma等一区及TOP SCI期刊审稿专家。
研究方向和兴趣：
1. 脓毒症发病机制及治疗靶点开发
2. 天然免疫调控与疾病发生基础
3. 免疫与代谢、衰老的交互影响
2013/9-2018/7: 暨南大学医学院，硕博连读，医学博士。
2001/9-2006/7: 安徽医科大学药学院，临床药理学，医学学士。
2025-至今: 暨南大学基础医学与公共卫生学院，病理生理学系，教授；
2019/1-2024/12: Department of Immunology, University of Connecticut Health Center (USA), Postdoctoral Fellow.
1. Duomeng Yang* (独立一作兼通讯作者), Jason G Cahoon, Tingting Geng, Chengliang Wang, Andrew G. Harrison, Evelyn Teran, Yanlin Wang, Anthony T. Vella, Vijay Rathinam, Jianbin Ruan, Penghua Wang*. Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1. bioRxiv. 2024 Dec, Revision in process.
2. Andrew G. Harrison, Duomeng Yang* (通讯作者), Jason G. Cahoon, Tingting Geng, Ziming Cao, Timofey Karginov, Conner C. Chiari, Xin Li, Yibing Qyang, Anthony T. Vella, Zhichao Fan, Sivapriya K. Vanaja1, Vijay A. Rathinam, Carol A. Witczak, Jonathan S. Bogan and Penghua Wang*. UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling. Nature Immunology. 2024 Dec;25(12):2234-2246. (SCI, Q1, IF:27.7).
3. Duomeng Yang* (独立一作兼通讯作者), Tingting Geng, Andrew G. Harrison, Jason G Cahoon, Jian Xing, Baihai Jiao, Mark Wang, Chao Cheng, Robert E. Hill, Huadong Wang, Anthony T. Vella, Gong Cheng, Yanlin Wang, Penghua Wang*. UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors. Nature Communications. 2024 Jan 26;15(1):780. (SCI, Q1, IF:14.7).
4. Duomeng Yang (独立一作), Tingting Geng, Andrew G Harrison, Penghua Wang*. Differential roles of RIG-I like receptors in SARS-CoV-2 infection. Military Medical Research. 2021 Sep 7;8(1):49. (SCI, Q1, IF:34.9).
5. Tingting Geng#, Duomeng Yang#(共同一作), Tao Lin, Andrew G. Harrison, Binsheng Wang, Ziming Cao, Blake Torrance, Zhichao Fan, Kepeng Wang, Yanlin Wang, Long Yang, Laura Haynes, Gong Cheng, Anthony T. Vella, Richard A. Flavell, Joao Pereira, Erol Fikrig, Penghua Wang. UBXN3B is crucial for B lymphopoiesis. EBioMedicine. 2024 Jul; 106, 105248. (SCI, Q1, IF:9.7).
6. Duomeng Yang (一作), Xiaomeng Dai, Yun Xing, Xiangxu Tang, Guang Yang, Andrew G Harrison, Jason Cahoon, Hongmei Li, Xiuxiu Lv, Xiaohui Yu, Penghua Wang, Huadong Wang*. Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction. Communications Biology. 2022 Jan 25;5(1):96. (SCI, Q1, IF:6.5).
7. Duomeng Yang (独立一作), Tao Lin, Cen Li, Andrew G Harrison, Tingting Geng, Penghua Wang*. A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system. iScience. 2021 Jun 1;24(6):102678. (SCI, Q1, IF:6.1).
8. Yaqian Xu, Xue Zhang, Xiangxu Tang, Chanjuan Zhang, Yingwei Wang, Hongmei Li, Xiuxiu Lv, Yiyang Wang, Zhi Wang, Huadong Wang*, Duomeng Yang* (通讯作者). Dexmedetomidine posttreatment exacerbates metabolic disturbances in septic cardiomyopathy via α2A-adrenoceptor. Biomedicine & Pharmacotherapy. 2024 Jan; 170:115993. (SCI, Q1, IF:7.5).
9. Tian Tian, Yu Qing, Duomeng Yang#(共同一作), Xue Zhang, Chanjuan Zhang, Jianling Li, Tao Luo, Xiuxiu Lv, Yiyang Wang, Huadong Wang, Hongmei Li*. Endothelial α1-adrenergic receptor activation improves cardiac function in septic mice via PKC-ERK/p38MAPK signaling pathway. International Immunopharmacology. 2024 Aug: 141:112937. (SCI, Q1, IF:4.8).
10. Yongliang Yuan, Baihai Jiao, Lili Qu, Duomeng Yang* (通讯作者), Ruijuan Liu*. The development of COVID-19 treatment. Frontiers in Immunology. 2023 Jan 26:14:1125246. (SCI, Q1, IF:7.3, ESI高被引).
11. Duomeng Yang (独立一作), Junmin Xi, Yun Xing, Xiangxu Tang, Xiaomeng Dai, Kaiying Li, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang*. A new method for neonatal rat ventricular myocyte purification using superparamagnetic iron oxide particles. International Journal of Cardiology, 2018 Nov 1;270:293-301. (SCI, Q1, IF:6.2).
中国病理生理学会炎症发热感染低温专委会第16次联合学术会议青年论坛一等奖。
暨南大学优秀博士论文奖。
中国病理生理学会会员
Military Medical Research科学编辑；
Nature Communications, Emerging Microbes & Infections, Free Radical Biology and Medicine, Burns & Trauma等一区及TOP SCI期刊审稿人。