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职称：副教授
学科专业：病理学
研究方向：外泌体液体活检，炎症，肿瘤干细胞，肿瘤微环境，肿瘤转移
行政职务
电子邮箱：hmdong@jnu.edu.cn
个人介绍：董洪梅，博士，副教授，博士研究生导师，暨南大学基础医学与公共卫生学院病理系肿瘤精准医学和病理研究所。中国抗癌协会肿瘤标志专业委员会青年委员、广东省抗癌协会委员。Cancer Letters，Oncogene和Annals of Medicine等杂志的审稿专家。先后主持和参加国家自然科学基金和广东省自然科学基金十余项。目前以第一作者和通讯作者身份在Clin Cancer Res, PNAS, Cancer Letters，Oncogene, journal of pathology，Matrix Biology，JCI Insight等主流杂志发表论文多篇。获广东省科技进步奖、广东省医学科技奖等多项奖励。
2018-至今，暨南大学，基础医学与公共卫生学院病理学系 讲师，副教授
2014/09-2017/06，汕头大学，生物化学与分子生物学，博士研究生
2009/09-2012/06，汕头大学，生物化学与分子生物学，硕士研究生
2005/09-2009/06，哈尔滨医科大学，公共卫生事业管理，学士
1. Lin Y#, Dong H#, Deng W#, Lin W, Li K, Xiong X, Guo Y, Zhou F, Ma C, Chen Y, Ren H, Yang H, Dai N, Ma L, Meltzer SJ, Yeung SJ, Zhang H*. Evaluation of salivary exosomal chimeric GOLM1-NAA35 RNA as a potential biomarker in esophageal carcinoma. Clin Cancer Res, 2019, 25(10): 3035-3045. IF: 10.11/A1 TOP
2. Yang Y#, Chen Z#, Chu X#, Yan Q, He J, Guo Y, Zhao Z, Zhang Y, Hu D, Ding H, Zhao X, Pan Y, Dong H*, Wang L*, Pan J*: Targeting LAYN inhibits colorectal cancer metastasis and tumor-associated macrophage infiltration induced by hyaluronan oligosaccharides. Matrix Biol, 2023, 117:15-30. IF:10.45/A1 TOP
3. Hongmei Dong#, Wan Lin#, Liang Du#, Zhimeng Yao, Yichen Luo, Feifei Li, Shuanglong Chen, Yiteng Huang, Sai-Ching Jim Yeung*, and Hao Zhang*. PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET. Cancer lett. 2023, 28:567:216283. IF: 9.7/A1 TOP
4. Yao Z#, Dong H#, Zhu J#, Du L#, Luo Y#, Liu Q, Liu S, Lin Y, Wang L, Wang S, Wei W, Zhang K, Huang Q, Yu X, Zhao W, Xu H, Qiu X, Pan Y, Huang X, Yeung SC, Zhang D, Zhang H*. Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment. JCI Insight, 2023,24;8(14):e166306. IF: 9.49/A1 TOP
5. Dong H#, Ma L#, Gan J, Lin W, Chen C, Yao Z, Du L, Zheng L, Ke C, Huang X, Song H, Kumar R, Yeung SC, Zhang H*: PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2. Oncogene, 2017, 36(3): 410-422. IF: 8.756/A1 TOP
6. Dong H#, Xu J#, Li W#, Gan J, Lin W, Ke J, Jiang J, Du L, Chen Y, Zhong X, Zhang D, Yeung SC, Li X, Zhang H* Reciprocal androgen receptor/interleukin-6 crosstalk drives oesophageal carcinoma progression and contributes to patient prognosis. J Pathol, 2017, 241: 448–462. IF: 9.883/A1 TOP
7. Gan J#, Ke X#, Jiang J#, Dong H#, Yao Z, Lin Y, Lin W, Wu X, Yan S, Zhuang Y, Chu W, Cai R, Zhang X, Cheung NS, Block NL, Pang C, Schally AV*, Zhang H*: Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1–STAT3/NF-κB signaling. Proc Natl Acad Sci U S A, 2016, 113(51): 14745-14750. IF: 11.1/A1 TOP
8. Ruijun Zhao#, Shuanglong Chen#, Weiheng Cui#, Chaoyu Xie, Aiping Zhang, Li Yang, Hongmei Dong*. PTPN1 is a prognostic biomarker related to cancer immunity and drug sensitivity: from pan-cancer analysis to validation in breast cancer. Front Immunol. 2023 Oct 23:14:1232047. IF: 8.786
9. Dong H#, Xie C#, Yao Z#, Zhao R#, Lin Y, Luo Y, Chen S, Qin Y, Chen Y* and Zhang H*. PTPRO-related CD8+ T cell signatures predict prognosis and immunotherapy response in patients with breast cancer. Front. Immunol, 2022; 13: 947841. IF: 8.786
10. Xie F#, Dong H#*, Zhang H*. Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells. Front. Immunol, 2021, 22:783370. IF: 8.786
11. Dong H#, Du L#, Cai S#, Wan Lin#, Chen C, Stil M, Yao Z, Coppes RP, Pan Y, Zhang D, Gao S*, Zhang H*: Tyrosine Phosphatase PTPRO Deficiency in ERBB2-Positive Breast Cancer Contributes to Poor Prognosis and Lapatinib Resistance. Front. Pharmacol, 2022, 13:838171. IF: 5.6
12. Dong H#, Xie C#, Jiang Y#, Li K, Lin Y, Pang X, Xiong X, Zheng J, Ke X, Chen Y, Li Y, Zhang H*: Tumor-Derived Exosomal Protein Tyrosine Phosphatase Receptor Type O Polarizes Macrophage to Suppress Breast Tumor Cell Invasion and Migration. Front Cell Dev Biol, 2021, 9:703537. IF: 6.081
13. Dong H#, Xie L#, Tang C, Chen S, Liu Q, Zhang Q, Zheng W, Zheng Z, Zhang H*: Snail1 correlates with patient outcomes in E-cadherin-preserved gastroesophageal junction adenocarcinoma. Clin Transl Oncol, 2014, 16(9): 783-791. IF: 3.4
14. Dong H#, Guo H#, Xie L, Wang G, Zhong X, Khoury T, Tan D, Zhang H*: The metastasis-associated gene MTA3, a component of the Mi-2/NuRD transcriptional repression complex, predicts prognosis of gastroesophageal junction adenocarcinoma. PloS One, 2013, 8(5): e62986. IF: 3.7
15. Gan J, Zhang Y, Ke X, Tan C, Ren H, Dong H, Jiang J, Chen S, Zhuang Y, Zhang H*: Dysregulation of PAK1 Is Associated with DNA Damage and Is of Prognostic Importance in Primary Esophageal Small Cell Carcinoma. Int J Mol Sci, 2015, 16(6): 12035-12050. IF:5.6
16. Feng Y, Ke C, Tang Q, Dong H, Zheng X, Lin W, Ke J, Huang J, Yeung SC, Zhang H*: Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell death & disease, 2014, 5: e1088. IF:9.0
17. Li Z, Zou X, Xie L, Dong H, Chen Y, Liu Q, Wu X, Zhou D, Tan D, Zhang H*: Prognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma. PloS one, 2013, 8(11): e80665. IF:3.7
1.食管癌肿瘤标志物及液体活检的应用与开发，广东省科技厅，广东省科技进步奖，二等奖，2021
2.食管癌早期诊断和治疗新方法的转化研究，广东省医学会，广东省医学会科技进步奖，二等奖，2019
3.上消化道肿瘤诊断和治疗新方法的转化研究，汕头市人民政府，汕头市科学技术奖励，一等奖，2018
1.中国抗癌协会肿瘤标志专业委员会青年委员
2.中国抗癌协会肿瘤标志专业委员会-外泌体技术专家委员会秘书
3.广东省抗癌协会委员
Cancer Letters, Oncogene, Annals of Medicine 等杂志的审稿专家。