系统生物医学 教授
职称：教授
学科专业：系统生物医学
研究方向：多组学、人工智能、衰老、肿瘤免疫
行政职务：系统生物医学系主任
电子邮箱：luojh@jnu.edu.cn
个人介绍：罗钧洪，医学科学博士，暨南大学教授、博士生导师。国家引进海外高层次人才计划青年人才（第十六批），国家自然科学基金外国优秀青年学者，广东省珠江人才计划引进高层次人才，回国前曾在澳大利亚联邦科学与工业研究组织任研究员（终身制）。主要研究方向为生物信息学、多组学和人工智能，长期从事生物医学多组学大数据相关研究，专注于人工智能技术在单细胞测序、T细胞受体组库和其它生物医学多组学分析中的开发和应用。在Cell、Nature、Nat Aging、Nat Genetics、Nat Protocols、Nat Comms、Sci Adv和STTT等顶级期刊发表30余篇学术论文，获授权美国专利1项，国家发明专利6项。
2007.8–2011.6，澳大利亚国立大学，医学科学，博士
2002.7–2006.6，澳大利亚新南威尔士大学，生物信息学，工程学士（Hounors degree）
2019.6至今，暨南大学，基础医学与公共卫生学院，教授
2016.8-2019.5，澳大利亚联邦科学与工业研究组织，Health & Biosecurity，研究员（Tenured)
2016.3-2016.7，美国杰克逊实验室基因组医学研究所，Genome Sciences，助理研究员
2012.9-2016.3，美国杰克逊实验室基因组医学研究所，Genome Sciences，博士后，合作导师：阮一骏
2011.7-2012.9，新加坡基因组研究所(GIS)，Genome Technology and Biology，博士后，合作导师：阮一骏
2006.7-2007.7，澳大利亚悉尼大学，兽医学院，生物信息科研员
1. Wenpu Lai; Yangqiu Li; Oscar Junhong Luo; MIST: an interpretable and flexible deep learning framework for single-T cell transcriptome and receptor analysis.Science Advances, 2025, 11(14): eadr7134
2. Yang Y*, Xiao C*, Zou D*, Wang L*, … , Chen G#, Li T#, Luo OJ#, Jiang W#. (2025). Deep learning-enabled multiphoton microscopy predicts colorectal cancer recurrence from routine FFPE specimens. NPJ Digit Med. 8(1):689.
3. Li YS*, Lai W*, Yin K*, Tu HY*, Li L, …, Li Y#, Luo OJ#, Zheng MM#, Wu YL#. (2025). Cellular dynamics in cerebrospinal fluid unveils the key regulators of intracranial response to immune checkpoint inhibitors in NSCLC brain metastases. J Immunother Cancer.13(11):e012071.
4. Sui S*, Wei X*, Zhu Y*, Feng Q, Zha X, Mao L, Huang B, Lei W, Chen G, Zhan H, Chen H, Feng R#, Zeng C, Li Y, Luo OJ#. (2025) Single-Cell Multiomics Reveals TCR Clonotype-Specific Phenotype and Stemness Heterogeneity of T-ALL Cells. Cell Prolif. 58(4):e13786.
5. Wenpu Lai*, Qiuyue Feng*, Wen Lei*, … , Hao Wang#, Zhenhua Li#, Guobing Chen#, Oscar Junhong Luo#. (2025). Deciphering Immunosenescence From Child to Frailty: Transcriptional Changes, Inflammation Dynamics, and Adaptive Immune Alterations. Aging Cell, 24(7):e70082.
6. Ai R*, Mao L*, Jin X*, Campos-Marques C*, … , Silva JM#, Luo OJ#, Fang EF#. (2025) NAD+ reverses Alzheimer‘s neurological deficits via regulating differential alternative RNA splicing of EVA1C. Science Advances. 11(45):eady9811.
7. Li, Xiaobo*; Yan, Sishan*; Wu, Xiaoyu*; …, Luo, Oscar Junhong#; Zhang, Dongmei#; Ye, Wencai#; Chen, Minfeng#. (2025) Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics. Nature Communications, 16(1): 7115.
8. Xiao Yang*, Yalei Wen*, Shengying Qin*, Yang Zhou*, … , Oscar Junhong Luo#, Xiangchun Shen#, Rutao Cui#, Tongzheng Liu#. (2025). UFMylation maintains tumor suppressor pVHL stability by activating the deubiquitinase BAP1. Science Advances, 11(28), adt8800.
9. Li YS*, Lai WP*, Yin K*, Zheng MM*, … , Li Y, Luo OJ#, Wu YL#. (2024) Lipid-associated macrophages for osimertinib resistance and leptomeningeal metastases in NSCLC. Cell Rep. 43(8):114613.
10. Chao Ke*; Boya Huang*; Jian Xiang*; Jinlian Liang*; … ; Guobing Chen#; Oscar Junhong Luo#; Hongyi Zhang#. (2024) Secreted Clusterin Inhibits Tumorigenesis by Modulating Tumor Cell and Macrophage in Human Meningioma. Neuro-Oncology, 26(noae034)
11. Bei Zhang*, Zhiyao Ren*, Jianfu Zhao*, Yue Zhu*, … , Hongyi Zhang#, Guobing Chen#, Oscar Junhong Luo#. (2023). Global analysis of HLA-A2 restricted MAGE-A3 tumor antigen epitopes and corresponding TCRs in non-small cell lung cancer. Theranostics, 13(13):4449-4468.
12. Xiao, C., Ren, Z., Zhang, B., Mao, L., Zhu, G., … Zhang, H., Wang, P.#, Liang, X.#, Luo, O.J.#, Chen, G.#. (2023). Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults. Nature Aging, 3(3)
13. Luo, O. J*#., Lei, W.*, Zhu, G.*, Ren, Z.*, … , Chen, G. (2022). Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty. Nature Aging, 2(4), 348–364.
14. Di, B.*, Jia, H.*, Luo, O. J.*, Lin, F.*, Li, K., Zhang, Y., Wang, H., Liang, H., Fan, J., & Yang, Z. (2020). Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics. Signal Transduction and Targeted Therapy, 5(1), 217.
15. Li, X.*, Luo, O. J.*, … , Ruan, Y. (2017). Long-read ChIA-PET for base-pair-resolution mapping of haplotype-specific chromatin interactions. Nature Protocols, 12(5), 899–915.
16. Tang, Z.*, Luo, O. J.*, Li, X.*, … , Ruan, Y. (2015). CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription. Cell, 163(7), 1611–1627.
The Jackson Laboratory Community Award, The Jackson Laboratory, 2015
CSIRO Julius Award, 澳大利亚联邦科学与工业研究组织, 2018
暨南大学基础医学与公共卫生学院科研工作先进个人，2020,2023
暨南大学基础医学与公共卫生学院突出贡献个人，2025
暨南大学第九届学术委员会委员
广东省医学会医学人工智能分会第一届委员会委员
广东省医学会老年医学分会第九届委员会老年免疫学组成员
广东省精准医学应用学会单细胞科技分会会员
