药理学 教授
职称:教授
学科专业:药理学
研究方向:小分子/多肽药物活性及机制研究;抗肿瘤化合物筛选,活性及机制研究;肿瘤相关蛋白功能及信号传导通路方面的研究;基于蛋白-蛋白相互作用的靶标的发现和研究
行政职务:靶向临床药物转化中心副主任
电子邮箱:qiqikc@jnu.edu.cn
个人介绍:
齐琦,暨南大学基础医学院与公共卫生学院药理学系,教授,博导。致力于药理学及肿瘤细胞生物学研究。迄今为止(2024)发表论文123篇,SCI论文105篇,H指数42。其中包括国际知名杂志PNAS, Mol Psychiatry, Adv Sci, Acta Pharm Sin B, Redox Biol,Oncogene在内SCI第一/通讯作者论文40篇。研究成果获得国内外同行的广泛关注和高度肯定。现是包括Cancer research,Drug Resistance Updates,Cancer letters,Acta Pharmaceutica Sinica B,Journal of Advanced Research,Journal of Experimental & Clinical Cancer Research在内的40家SCI收录杂志的特邀审稿人。Molecular and Cellular Biochemistry(二区), Biochemical Pharmaocology(二区,TOP)编委,《中国临床药理学及治疗学》编委;《肿瘤药理学》(2008,北京,化学工业出版)《药理学》(2021,北京,中国医药科技出版社)教材编委。主持国家自然科学基金面上项目两项,广东省自然科学基金一项,广州市基础与应用基础研究项目一项。国家自然科学基金和广东省自然科学基金评审专家。中国抗癌协会抗癌药物专业委员会青年委员会副主任委员,广东省药理学会肿瘤药理学专业委员会常务委员,广东省药理学会药物筛选与评价专业委员会常务委员,广东省抗癌协会抗肿瘤药物专业委员会委员,美国癌症研究协会,国际化学生物学学会,中国细胞生物学学会,中国药理学会及中国生物化学与分子生物学会会员。
2006-2009,中国药科大学,药理学博士学位
2003-2006,中国药科大学,药理学硕士学位
1999-2003,郑州大学,药学学士学位
2018.6-至今,暨南大学基础医学与公共卫生学院药理系 教授
2016.11-2018.5,埃默里大学医学院药理系化学生物学研发中心 Instructor (美国)
2015.3-2016.10,埃默里大学医学院药理系化学生物学研发中心Research Associate (美国)
2010.8-2015.2,埃默里大学医学院病理和实验医学系博士后(美国)
2009.8-2010.7,西弗吉尼亚大学医学院生理系伦道夫玛丽巴布癌症中心博士后(美国)
近五年SCI论文
1. Zou Q Zhou X, Lai J, Zhou H, Su J, Qi Q et al. Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment. Redox Biol. 2024 Dec 4.103460. (通讯作者,一区)
2. Fan S, Yan X, Hu X, Liu X, Qi Q, Chen Y et al. Shikonin blocks CAF-induced TNBC metastasis by suppressing mitochondrial biogenesis through GSK-3β/NEDD4-1 mediated phosphorylation-dependent degradation of PGC-1α. J Exp Clin Cancer Res. 2024 Jun 27;43(1):180. (通讯作者,一区)
3. Lai JQ, Zhao LL, Hong C, Zou QM, Su JX, Qi Q et al. Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis. Acta Pharmacol Sin. 2024 Aug;45(8):1715-1726. (通讯作者,一区)
4. Tu H, Zhou X, Zhou H, Luo Z, Yan Y, Luo Z, Qi Q. Anti-tumor effect and mechanisms of Timosaponin AIII across diverse cancer progression. Biochem Pharmacol. 2024 Oct;228:116080. (通讯作者,二区TOP)
5. Fan S, Qi M, Qi Q, Miao Q, Zhang D, Ye W, Chen M et al. Targeting FAP α-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis. Acta Pharm Sin B. 2024 Feb;14(2):682-697. (第一作者,一区)
6. Wang F, Qi Q, Qin B, Li K, Jiang Z, Zhang H et al. Targeting VCP potentiates immune checkpoint therapy for colorectal cancer. Cell Rep. 2023 Qct 21;42(11):113318. (第一作者,一区)
7. Li X, Qi Q, Li Y, Chen M, Ye W, Zhang D et al. TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold-Sensing TRPM8 Channel. Adv Sci. 2023 Aug 27;e2302717. (第一作者,一区)
8. Wang C, Yu C, Chang H, Song J, Qi Q, Shan C et al. Glucose-6-phosphate dehydrogenase: a therapeutic target for ovarian cancer. Expert Opin Ther Targets. 2023 Jul-Dec;27(8):733-743. (通讯作者,二区)
9. Luo H, Zhang C, He L, Qi Q, Chen JX, Yao W et al. 18β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype. Psychopharmacology. 2023 Sep;240(9):1947-1961. (通讯作者,二区)
10. Su JX, Li SJ, Zhou XF, Zhang ZJ, Yan Y, Liu SL, Qi Q. Chemotherapy-induced metastasis: molecular mechanisms and clinical therapies. Acta Pharmacol Sin. 2023 Sep;44(9):1725-1736. (通讯作者,一区)
11. Zhang Y, Song Y, Ren S, Qi Q, Shen X, Chen Y et al. GPER-mediated stabilization of HIF-1α contributes to upregulated aerobic glycolysis in tamoxifen-resistant cells. Oncogene. 2023 Jan;42(3):184-197. (通讯作者,一区)
12. Cao Q, Luo S, Yao W, Chen J, Hashimoto K, Qi Q, Zhang JC et al. Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology. Mol Ther Nucleic Acids. 2022 Sep 13;29:1-15. (通讯作者,一区)
13. Yao W, Cao Q, Luo S, He L, Yang C, Chen J, Qi Q, Hashimoto K, Zhang JC. Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine. Mol Psychiatry. 2022 Mar;27(3):1618-1629. (通讯作者,一区)
14. Tang R, Cao QQ, Hu SW, Sun YR, Zhang JC, Qi Q et al. Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription. Acta Pharmacol Sin. 2022 Apr;43(4):829-839. (通讯作者,一区)
15. Liu C, Yang D, Wang H, Hu S, Xie X, Zhang L, Jia H, Qi Q. MicroRNA-197-3p mediates damage to human coronary artery endothelial cells via targeting TIMP3 in Kawasaki disease. Mol Cell Biochem. 2021 Dec;476(12):4245-4263. (通讯作者,二区)
16. Li CL, Li J, Gong S, Huang M, Qi Q, Yin X et al. Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis. Acta Pharmacol Sin. 2021 Nov;42(11):1847-1859. (通讯作者,一区)
17. Li Z, Su J, Sun M, Song J, Shan C, Qi Q, Zhang S et al. Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer. Mol Cell Biochem. 2021 Sep;476(9):3423-3431. (通讯作者,二区)
18. Yao W, Lin S, Su J, Hashimoto K, Qi Q, Zhang JC et al. Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents. Transl Psychiatry. 2021 Feb 24;11(1):140. (通讯作者,一区)
19. Xu M, Qi Q, Men L, Wang S, Li M, Xiao M, Chen X, Wang S, Wang G, Jia H, Liu C. Berberine protects Kawasaki disease-induced human coronary artery endothelial cells dysfunction by inhibiting of oxidative and endoplasmic reticulum stress. Vascul Pharmacol. 2020 Apr;127:106660. (第一作者,二区)
20. Li X, Tang X, Su J, Xu G, Zhao L, Qi Q. Involvement of E-cadherin/AMPK/mTOR axis in LKB1-induced sensitivity of non-small cell lung cancer to gambogic acid. Biochem Pharmacol. 2019 Sep 9;169:113635. (通讯作者,二区TOP)
1.《Renin-Angiotensin in Cancer, Lung, Liver and Infectious Diseases》2022, “Advances in Biochemistry in Health and Disease”Book Series, Springer Nature Switzerland AG, 参编;
2.《药理学》2021,“十四五”规划教材,北京,中国医药科技出版社,参编;
3.《肿瘤药理学》2008,“研究生教材”北京,化学工业出版, 参编
Acta Pharmacologica Sinica (A1一区) 优秀审稿人奖 2022
Acta Pharmacologica Sinica 优秀审稿人奖 2022
Acta Pharmacologica Sinica 优秀审稿人奖 2018
Acta Pharmacologica Sinica 优秀审稿人奖 2016
受邀评审专家
国家自然科学基金
广东省自然科学基金
湖南省自然科学基金
江西省自然科学基金
广西自然科学基金
杂志编委
《Molecular and Cellular Biochemistry》
《Biochemical Pharmacology》
《中国临床药理学与治疗学》
受邀40家SCI收录杂志审稿人
Cancer Research (12.701); Drug Resistance Updates (15.8); Journal of Advanced Research (11.4); Acta Pharmaceutica Sinica B (11.403); Journal of Experimental & Clinical Cancer Research (11.161); Cancer letters (8.679); International Journal of Biological Macromolecules (7.70); Cell Death & Disease (8.469); Free Radical Biology and Medicine (7.376), Oxidative Medicine and Cellular Longevity (7.31), Food and Chemical Toxicology (6.026); Acta Pharmacologica Sinica (6.15); Biomedicine&Pharmacotherapy (6.9); Biochemical Pharmacology (5.858); Cell Death Discovery (5.241); Laboratory Investigation (5.662); Phytomedicine (5.34); Journal of Molecular Medicine (4.599); Journal of Cellular and Molecular Medicine (5.31); Frontiers in Pharmacology (5.81); Journal of Ethnopharmacology (4.8); Molecular Pharmacology (4.436); Investigational New Drugs (3.85); BMC Cancer (4.43); International Immunopharmacology (4.8); Journal of Oncology (4.375); Toxicology (4.221); Cancer Management and Research (3.989); Basic &Clinical Pharmacology & Toxicology (4.08); OncoTargets and Therapy (4.147); Journal of Cellular Biochemistry (4.429); European Journal of Pharmacology (4.432); PLOS One (2.806); Molecular and Cellular Biochemistry (3.396); Pharmacological Reports (2.587); Oncology Letters (3.24); Molecular Medicine Reports (2.952); Gene (2.6); Neoplasma (2.575);