病理生理学 教授
职称：教授
学科专业：病理生理学
研究方向：泛素化修饰及脓毒症心功能障碍的发病机制
行政职务：学科建设与发展中心副主任
个人简介：
王一阳，暨南大学基础医与公共卫生学院教授，医学博士，博士生导师，“暨南双百英才计划”。
近年来主要进行泛素化修饰信号通路在炎症和肿瘤等疾病发生发展过程中的作用机制研究。主持国家自然科学基金面上项目，获得暨南双百英才计划资助。在国内外优秀杂志发表论文20余篇，其中包括第一或通讯作者在Nature Communications，Science Advances，J Am Chem Soc，Cell Chemical Biology，FASEB J，Critical Care等一区或Top论文近10篇，担任SCI杂志Cardiology Research and Practice的编委。主持教改项目两项。
2007至2013年于暨南大学医学院病理生理学系攻读硕士和博士学位，主要进行脓毒症性心功能障碍方面的研究。
2013年博士毕业之后到美国乔治亚州立大学进行了三年的博士后研究工作，研究内容是通过对泛素化系统的改造，发现某些泛素连接酶E3的特异性靶蛋白。相关研究已经分别发表于Nature Communications和Science Advances。此后于2016年底到2018年7月，在美国Scripps研究所Peter Schultz院士课题组继续进行博士后的研究工作，主要进行针对治疗癌症的免疫检查点药物的开发与研究。合成了抗PD-L1/CTLA4抗体与小分子化合物的复合体；针对大肠杆菌E. coli基因组学的研究，发现了能诱导基因组DNA突变成RNA的基因，相关成果发表于杂志JACS(《美国化学会志》)。于2018年7月，通过暨南大学人才引进政策，进入暨南大学基础医学院病理生理学系任教。
1. Yiyang Wang, Xianpeng Liu, Li Zhou, Duc Duong, Karan Bhuripanyo, Bo Zhao, Han Zhou, Ruochuan Liu, Yingtao Bi, Hiroaki Kiyokawa, Jun Yin. Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer. Nature Communications. 2017, 8 (1): 2232.
2. Karan Bhuripanyo, Yiyang Wang, Xianpeng Liu, Li Zhou, Ruochuan Liu, Bo Zhao, Yingtao Bi, Han Zhou, Geng Chen, Nicholas T. Seyfried, Walter J.Chazin, Hiroaki Kiyokawa, Jun Yin. Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer. Science Advances. 2018, 4 (1): e1701393.
3. Angad P. Mehta, Yiyang Wang, Sean A. Reed, Lubica Supekova, Tsotne Javahishvili, John C. Chaput, Peter G. Schultz. Bacterial Genome Containing Chimeric DNA-RNA Sequences. J Am Chem Soc. 2018, 140 (36): 11464-11473.
4. Yiyang Wang, Shuai Fang, Geng Chen, Rakhee Ganti, Tatiana A. Chernova, Li Zhou, Duc Duong, Hiroaki Kiyokawa, Ming Li, Bo Zhao, Natalia Shcherbik, Yury O. Chernoff, and Jun Yin. Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer. Cell Chem Biol. 2021, 28(9):1283-1297.
5. Yiyang Wang, Ruochuan Liu, Jia Liao, Lucen Jiang, Geon H Jeong, Li Zhou, Monica Polite, Duc Duong, Nicholas T Seyfried, Huadong Wang, Hiroaki Kiyokawa, Jun Yin. Orthogonal ubiquitin transfer reveals human papillomavirus E6 downregulates nuclear transport to disarm interferon-γ dependent apoptosis of cervical cancer cells. FASEB J. 2021, 35(11): e21986.
6. Jia Liao, Kaiying Li, Xingyu Su, Yihua Chen, Yingwei Wang, Xiangxu Tang, Yun Xing, Yaqian Xu, Xiaomeng Dai, Jiashuo Teng, Hongmei Li, Huadong Wang, Xiuxiu Lv, Yiyang Wang. Dexmedetomidine Promotes LPS-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through alpha2A Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice. Int J Mol Sci, 2021, 22: 12749.
7. Lucen Jiang, Jia Liao, Jianghuan Liu, Qingzhu Wei, Yiyang Wang. Geranylgeranylace -tone promotes human osteosarcoma cell apoptosis by inducing the degradation of PRMT1 through the E3 ubiquitin ligase CHIP. J Cell Mol Med. 2021, 25(16): 7961-7972.
8. Yiyang Wang, Yuan Wang, Duomeng Yang, Xiaohui Yu, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang. β1-adrenoceptor stimulation promotes LPS-induced cardiomyocyte apoptosis through activating PKA and enhancing CaMKII and IκBα phosphorylation, Critical Care, 2015, 19 (1): 76.
9. Yiyang Wang, Hong-mei Li, Hua-dong Wang, Xuemei Peng, Yanping Wang, Daxiang Lu, Renbin Qi, Chaofeng Hu, Jianwei Jiang. Pretreatment with Berberine and Yohimbine Protects Against LPS-Induced Myocardial Dysfunction Via Inhibition of Cardiac I-κBα Phosphorylation and Apoptosis in Mice. Shock, 2011.11.3, 35(3): 322-328.
10. Yiyang Wang, Xiaohui Yu, Faqiang Wang, Yuan Wang, Yanping Wang, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang. Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockage of presynaptic α2A-adrenergic receptor. PLoS One. 2013; 8 (5): e63622.
11. Hongmei Li, Yiyang Wang, Huadong Wang, Wenjuan Cao, Xiaohui Yu, Daxiang Lu, Ren-bin Qi, Chaofeng Hu, Yuxia Yan. Berberine protects against Lipopolysaccharide induced intestinal injury in m ice in an alpha 2 adrenoceptor independent manner. Acta Pharmacol Sin , 2011, 32(11): 1364 1372.
12. Hui Li, Yiyang Wang, Haoqing Zhang, Baoyin Jia, Daan Wang, Hongmei Li, Daxiang Lu, Renbin Qi, Yuxia Yan, Huadong Wang. Yohimbine enhances protection of berberine against LPS-induced mouse lethality through multiple mechanisms. PLoS One. 2012, 7 (12): e52863.
《中华创伤休克学》（参编）
2020年暨南大学基础医学与公共卫生学院优秀科研工作者
担任SCI杂志Cardiology Research and Practice的编委
