病理学与病理生理学 副教授
职称：副教授
学科专业：病理学
研究方向：肿瘤免疫治疗、肿瘤转移、肿瘤干细胞、外泌体液体活检等
行政职务
电子邮箱：luwang2022@jnu.edu.cn
个人介绍：暨南大学基础医学与公共卫生学院副教授，暨南大学附属第一医院博士后。研究方向：我国高发恶性肿瘤的诊治的转化研究和应用，包括外泌体液体活检和免疫治疗。在研究领域一流期刊发表多篇学术论文，以第一作者发表SCI收录文章14篇，包括TOP期刊PNAS、NC、Drug Resist Update、Oncogene、Cancer Lett等，其中单篇最高他引次数将近160次。主持国家自然科学基金2项、省部级课题2项、中国博士后基金1项，参与了多项国家自然科学基金。广东省科技进步奖二等奖。
2015/09-2019/07，汕头大学，病理学与病理生理学，博士
2013/07-2015/08，汕头大学，病理学与病理生理学，硕士
2019-2021 暨南大学附属第一医院 博士后
2022年-至今 暨南大学基础医学与公共卫生学院
1. Wang L#, Liang D, Xiong X, Lin Y, Zhu J, Yao Z, Wang S, Guo Y, Chen Y,Geary K, Pan Y, Zhou F, Gao S, Zhang D, Yeung SJ, Zhang H*.Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. Oncogene 2021 Mar;40(11).
2. Wang L, Xiong X, Yao Z, Zhu J, Lin Y, Lin W, Li K, Xu X, Guo Y, Chen Y, Pan Y, Zhou F, Fan J, Chen Y, Gao S, Jim Yeung SC, Zhang H. Chimeric RNA ASTN2-PAPPAas aggravates tumor progression and metastasis in human esophageal cancer. Cancer Lett. 2021 Mar 31;501:1-11.
3. Wang L#, Li K#, Lin X#, Yao Z, Wang S, Xiong X, Ning Z, Wang J, Xu X, Jiang Y, Liu D, Chen Y, Zhang D, Zhang H*: Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis. Cancer Lett, 2019, 450: 22-31
4. Xiong X#, Ke X#, Wang L#, Yao Z, Guo Y, Zhang X, Chen Y, Pang CP, Schally AV*, Zhang H*: Splice variant of growth hormone-releasing hormone receptor drives esophageal squamous cell carcinoma conferring a therapeutic target. Proc Natl Acad Sci USA, 2020, 117(12): 6726-6732
5. Du L#, Wang L#, Gan J#, Yao Z, Lin W, Li J, Guo Y, Chen Y, Zhou F*, Jim Yeung SC, Coppes RP, Zhang D, Zhang H*: MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis. iScience, 2019, 22: 353-368
6. Wang L#, Li W#, Li K#, Guo Y, Liu D, Yao Z, Lin X, Li S, Jiang Z, Liu Q, Jiang Y, Zhang B, Chen L, Zhou F, Ren H, Lin D, Zhang D, Yeung SJ, Zhang H*: The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma. Cancer Med, 2018, 7(10): 5205-5216
7. Zheng L#, Wang L#, Gan J, Zhang H*: RNA activation: promise as a new weapon against cancer. Cancer Lett, 2014, 355(1): 18-24
8. Zhang Y#, Ren H#, Wang L#, Ning Z, Zhuang Y, Gan J, Chen S, Zhou D, Zhu H, Tan D, Zhang H*: Clinical impact of tumor-infiltrating inflammatory cells in primary small cell esophageal carcinoma. Int J Mol Sci 2014 May 30;15(6)
9. Yang Y, Chen Z, Chu X, Yan Q, He J, Guo Y, Zhao Z, Zhang Y, Hu D, Ding H, Zhao X, Pan Y, Dong H*, Wang L*, Pan J*. Targeting LAYN inhibits colorectal cancer metastasis and tumor-associated macrophage infiltration induced by hyaluronan oligosaccharides. Matrix Biol. 2023 Mar;117:15-30.
10. Zhu J#, Wang L#, Liu F, Pan J, Yao Z, Lin Y, Yang Y, Xiong X, Li K, Yang Y, Zhang Y, Chu X, Pan Y*, Zhang H*. Targeting PELP1 Attenuates Angiogenesis and Enhances Chemotherapy Efficiency in Colorectal Cancer. Cancers (Basel). 2022 Jan 13;14(2):383.
11. Xiong X, Ke X, Wang L, Lin Y, Wang S, Yao Z, Li K, Luo Y, Liu F, Pan Y, Yeung SJ, Helfrich W, Zhang H*: Neoantigen-based cancer vaccination using chimeric RNA-loaded dendritic cell-derived extracellular vesicles. J Extracell Vesicles. 2022 Aug;11(8):e12243.
广东省科技进步奖二等奖
中国抗癌协会感染肿瘤专委会
