系统生物医学 教授
职称：教授
学科专业：系统生物医学
研究方向：单细胞三维基因组、生殖系发育、基因表观调控
行政职务：无
电子邮箱：jiansenlu@jnu.edu.cn
个人简介：理学博士，教授，博士生导师。主要从事新型单细胞组学技术开发及应用，重点关注早期胚胎及生殖系发育，开发了国际上首个基于单分子测序平台的单细胞三维基因组技术及高阶互作分析算法，揭示了胚胎生殖细胞减数分裂的表观调控机制，以第一作者（含共同）和通讯作者在Nature Methods, Nature Structural & Molecular Biology, Nature communications, Cell Discovery，Protein & Cell, Cell Reports, Cell Proliferation和MedComm杂志上共发表文章8篇，其中2项成果获期刊专栏评述。获得北京大学博雅博士后等荣誉，主持博士后面上项目（第78批）。
2019.09—2024.07 北京大学，细胞生物学，博士；导师：汤富酬教授
2015.09—2019.07 武汉大学，生物科学，学士。
1. Jiansen Lu#, Kexuan Chen, Shengtao Jia, Guodong Chen, Xianhong Yu# and Wen Li#. A droplet-based long-read single-cell epigenome sequencing method for the high-throughput profiling of multidimensional regulatory elements within individual cells. Cell Discovery(2026) DOI: 10.1038/s41421-026-00928-y, accepted.
2.Jiansen Lu*, Wen Li*, Fuchou Tang#. Single-cell long-read Hi-C, scNanoHi-C2, details 3D genome reorganization in embryonic-stage germ cells. Nature Structural & Molecular Biology (2025) doi: 10.1038/s41594-025-01604-7.
3.Wen Li*, Jiansen Lu*, …, Fuchou Tang#. scNanoHi-C: a single-cell long-read concatemer sequencing method to reveal high-order chromatin structures within individual cells. Nature Methods (2023) doi: 10.1038/s41592-023-01978-w.
4.Jiansen Lu*, Jie Ren*, Jie Liu*, …, Jizheng Wang#, Shuiyun Wang#, Lu Wen#, Lei Song#. High-resolution single-cell transcriptomic survey of cardiomyocytes from patients with hypertrophic cardiomyopathy. Cell Proliferation (2023) doi: 10.1111/cpr.13557.
5.Qing Li*, Jiansen Lu*, Xidi Yin*, Yunjian Chang*, Chao Wang*, Meng Yan*, …, Guo-Liang Xu#, Ligang Wu#, Fuchou Tang#, Jinsong Li#. Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation. Nature Communications (2023) doi: 10.1038/s41467-023-38528-z.
6.Yuhan Chen*, Jiansen Lu*, Yanwen Xu*, Yaping Huang*, Dazhuang Wang*, …, Mei Wang#, Fuchou Tang#, Xiao-Yang Zhao#. The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting. Protein & Cell (2023) doi: 10.1093/procel/pwac044.
7.Jingyi Li*, Jiansen Lu*, Jiayu Chen*, …, Shaorong Gao#, Fuchou Tang#. Multi-omics analysis reveals single-cell meiotic hotspot dynamics and epigenetic regulations in female mammals. Cell Reports (2025) doi: 10.1016/j.celrep.2025.116082.
8.Jingwei Yang*, Shuyue Qi*, Yuan Gao*, Jiansen Lu*, …, Fuchou Tang#, Xin Zhou#. Systematic identification of molecular signatures dictating therapeutic effects of clinically first-line chemotherapy regimens for human gastric cancer patients based on organoid model. MedComm (2026) doi: 10.1002/mco2.70656.
9.J Dong*, P Zhou*, Y Wu*, Y Chen*, H Xie, Y Gao, J Lu, J Yang, X Zhang, L Wen, T Li#, F Tang#. Integrating single-cell datasets with ambiguous batch information by incorporating molecular network features. Brief. Bioinform. (2022) doi: 10.1093/bib/bbab366;
10.H Xie*, W Li*, Y Hu, C Yang, J Lu, Y G, L Wen, F Tang#. De novo assembly of human genome at single-cell levels. Nucleic Acids Res. (2022) doi: 10.1093/nar/gkac586;
11.S Qin, Y Zhang, M Shi, D Miao, J Lu, L Wen, Y Bai#. In-depth organic mass cytometry reveals differential contents of 3-hydroxybutanoic acid at the single-cell level. Nat. Commun. (2024) doi: 10.1038/s41467-024-48865-2.
*共同第一作者，#共同通讯作者
2026.07—至今 暨南大学, 基础医学与公共卫生学院，教授；
2024.07-2026.07 北京大学，生命科学学院博士后。
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