系统生物医学 副教授
职称：副教授
学科专业：系统生物医学
研究方向：
1.医学生命组学与系统免疫学。
2.基于人工智能的多组学技术解析T细胞的发育、分化和功能。
电子邮箱：lizhenhua915@jnu.edu.cn
个人介绍：李振华，博士，硕士生导师，暨南大学基础医学与公共卫生学院系统生物医学系副教授，中国免疫学会和广东省免疫学会会员，担任Medicine Advances、Medical Data Mining、Traditional Medicine Research、eFood和hLife杂志青年编委以及Frontiers in Immunology客座编辑。
主要研究方向：1、医学生命组学与系统免疫学；2、基于人工智能的多组学技术在T细胞发育、分化和功能中的开发和应用。主持国家自然科学基金1项，中国博士后面上项目1项，广东省区域联合基金1项，参与国家自然科学基金面上项目2项，在Molecular Cancer、Aging Cell、Cell Reports、JAFC、Science Bulletin、Environmental science & technology、Frontiers in Immunology、Cell Death & Differentiation等SCI杂志上发表24篇研究论文，申请中国发明专利9件，授权5件，PCT专利3件。承担本科生课程《大学计算机基础》《人工智能与自然科学》《人工智能与医学生命组学》，研究生课程《生物医学大数据方法及应用》《医学生命组学与生物信息学》，指导本科生获“大创”国家级立项。
2016-09 至 2019-06 暨南大学，生物化学与分子生物学专业，博士
2013-09 至 2016-07 暨南大学，生物化学与分子生物学专业，硕士
2023-06至今：暨南大学基础医学与公共卫生学院，系统生物医学系，副教授
2021-08 至 2023-06 暨南大学附属珠海医院，基础医学，博士后
2019-07 至 2021-07 暨南大学附属第一医院，临床医学，博士后
已发表（共）第一/通讯作者论文
1.Yu Huang, Ying Xie, Yuqing Zhang, Zhemian Liu, Weihua Jiang, Yingying Ye, Jiale Tang, Zhenhua Li, Zhinan Yin, Xue-Jia Lin., 2025. Single-cell transcriptome reveals the reprogramming of immune microenvironment during the transition from MASH to HCC. Molecular Cancer. 24 (1), 177. (IF=33.9, I区top)
2.Wenpu Lai, Qiuyue Feng, Wen Lei, Chanchan Xiao, Juan Wang, Yi Zhu, Lipeng Mao, Yue Zhu, Jiacheng He, Yangqiu Li, Hao Wang, Zhenhua Li, Guobing Chen, Oscar Junhong Luo., 2025.Deciphering Immunosenescence From Child to Frailty: Transcriptional Changes, Inflammation Dynamics, and Adaptive Immune Alterations. Aging Cell. 0: e70082. (IF=8.0, I区top)
3.Junjie Yan, Yingying Zeng, Zerong Guan, Zhenhua Li, Shunchang Luo, Jie Niu, Junzhang Zhao, Haibiao Gong, Ting Huang, Zhongzhen Li, Anyi Deng, Qiong Wen, Jingyi Tan, Jun Jiang, Xiucong Bao, Sitao Li, Guodong Sun, Min Zhang, Min Zhi, Zhinan Yin, Wan-Yang Sun, Yi-Fang Li, Rong-Rong He, Guangchao Cao., 2024. Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis. Cell Reports. 43 (8), 114636. (IF=9.995, I区top)
4.Xusheng Li, Zhenhua Li, Dongbao Cai, Yawen Li, Yuanqin Zhu, Rui Jiao, Caiyong Lai, Jianxia Sun, Weibin Bai., 2023, Vitisin A, as a Type of Pyranoanthocyanin, Suppresses Inflammation by Restricting Hematopoietic Stem Cell Differentiation toward Monocytes in Bone Marrow. Journal of Agricultural and Food Chemistry. 71 (41): 15048-15063. (IF=5.7, I区top)
5.Zhenhua Li, Quanli Yang, Xin Tang, Yiming Chen, Shanshan Wang, Xiaojie Qi, Yawen Zhang, Zonghua Liu, Jing Luo, Hui Liu, Yongbing Ba, Lianxia Guo, Baojian Wu, Fang Huang, Guangchao Cao, Zhinan Yin., 2022. Single-cell RNA-seq and chromatin accessibility profiling decipher the heterogeneity of mouse γδ T cells. Science Bulletin. 67, 408-426. (IF=20.577, I区top)
6.Zhenhua Li, Xin Tang, Lingfei Zhu, Xiaojie Qi, Gang Cao, Gang Lu., 2020. Cytotoxic Screening and Transcriptomics Reveal Insights into the Molecular Mechanisms of Trihexyl Phosphate-Triggered Hepatotoxicity. Environmental Science & Technology. 54, 11464-11475. (IF=11.357, I区top)
7.Zhenhua Li, Xin Tang, Yu Luo, Bangyu Chen, Congcong Zhou, Xiuqing Wu, Zhenping Tang, Xiaojie Qi, Guangchao Cao, Jianlei Hao, Zonghua Liu, Qingmin Wang, Zhinan Yin, Hengwen Yang., 2019. NK007 helps in mitigating paclitaxel resistance through p38MAPK activation and HK2 degradation in ovarian cancer. Journal of Cellular Physiology. 234, 16178-16190. (IF=6.513, II区top)
广东省免疫学会2023年青年学者奖
广东省免疫学会2021年学术年会博后论坛二等奖
中国免疫学会和广东省免疫学会会员
Medicine Advances、Medical Data Mining、Traditional Medicine Research和eFood杂志青年编委以及Frontiers in Immunology客座编辑
