药理学 研究员
职称：研究员
学科专业：药理学
研究方向：中药活性成分研究
电子邮箱：ybzhang99@jnu.edu.cn
个人介绍：主要从事中药现代化研究与开发，对地胆草、绵马贯众、苦参等二十余种中草药活性成分进行研究，累计发现化合物1000余种（含新化合物500余种），4个化合物被《Natural Product Reports》（IF:15.111）评为“热点分子”。主持国家自然科学基金-面上/青年基金、博士后科学基金特别资助项目、博士后科学基金面上项目(一等资助)d等7项；以第一/通讯作者身份在Advance Science、Cancer Letters、Organic Letters、Chinese Chemical Letters等杂志发表SCI论文45篇，h-index=21，论文总被引超1000次；申请专利22项（授权8项），其中3项专利已转让；入选2019年广东省100位博士博士后创新人物称号。
2014.09―2017.06 暨南大学药学院 中药化学专业博士 导师：李药兰 教授
2011.09―2014.06 暨南大学药学院 药物化学专业硕士 导师：李药兰 教授
2007.09―2011.06 暨南大学药学院 药学专业学士
2024.10至今 暨南大学基础医学与公共卫生学院药理学系 研究员
2019.10―2024.10 暨南大学基础医学与公共卫生学院药理学系 副研究员
2017.08―2019.10 暨南大学中西医结合博士后流动站 博士后（合作导师：王国才 研究员）
1. Si-Yu Yang#, Hua-Yan Xie#, Qiang Lin#, Liu-Jin Zhou, Jun-Xi Liu, Ze-Kai Fang, Zi-Ling Tang,Rui-Jie Yuan, Jin-Xuan Su, Si-Jia Li, Wen-Lin Wang, Ming-Yu Pan, Hao Wang,* Xiao-Yong Dai,*Guo-Cai Wang,* and Yu-Bo Zhang*. EM2, a natural product MST1/2 kinase activator,suppresses non-small cell lung cancer via Hippo pathwayactivation. Advance Science, 2026, 13(1): e10508.
2. Qing Tang#, Kai Zhao#, Hui-Hui Zhu#, Qiang Lin, Hai-Yue Zhao, Wei-Xuan Zheng, Zhong-Nan Wu, Hao Wang*, Guo-Cai Wang*, Yu-Bo Zhang*. Pecanthines A–C, unprecedented dimeric β-carboline alkaloids from the seeds of Peganum harmala. Chinese Chemical Letters, 2025, in press. https://doi.org/10.1016/j.cclet.2025.112172
3. Ji-Hui Zhang, Hui-Lin Ou, Ting Lu, Si-Yu Yang, Ding Luo, Peng Wu, Yao-Lan Li, Neng-Hua Chen*, Guo-Cai Wang*, Yu-Bo Zhang*. Daphcalycines A–D, four highly rearranged Daphniphyllum alkaloids with cardioprotective activity from Daphniphyllum calycinum. Chinese Chemical Letters, 2026, 37(3): 111314.
4. Albert Yu,#Yi-Bo Hou,#Kai-Bin Huang,#Xu-Can Gao, Rong Zeng, Chao-Wei Zhu, Chun-Hui Sun, Guo-Cai Wang, Lei Ye, Shao-Hua Ma, Tian Meng,* Bing Guo,* Yu-Bo Zhang,* Xiao-Yong Dai*. Anti-CD47 antibody-decorated and cisplatin-containing mesoporous silica nanoparticles for targeted chemoimmunotherapy of colorectal cancer in a patient-derived organoids xenograft model. Interdisciplinary Medicine, 2026, Online Version 70075.
5. Zhi-Peng Ling#, Jun-Ping Pan#, Zhong-Fei Zhang#, Gui-Si Chen, Jia-Yuan Geng, Qiang Lin, Tao Zhang, Shu-Qin Cao, Cheng Chen, Jin-Rong Lin, Hong-Yao Yuan, Wei-Long Ding, Fei Xiao, Xin-Ke Xu, Fang-ChengLi, Guo-Cai Wang*, Yu-Bo Zhang*, Jun-Liang Li*. Small-molecule Molephantin induces apoptosis and mitophagy flux blockage through ROS production in glioblastoma. Cancer Letters 2024, 592: 216927.
6. Yi-Bo Hou#, Zi-Xian Wang#, Wen-Lin Wang#, Qing Tang, Yong-De Cai, Si-Yang Yu, Jin Wang, Xiu Yan, Guo-Cai Wang, Peter E Lobie, Yu-Bo Zhang*, Xiao-Yong Dai*, Shao-Hua Ma*. AI-identified CD133-targeting natural compounds demonstrate differential anti-tumor effects and mechanisms in pan-cancer models. EMBO Molecular Medicine. 2025, 17: 2932 - 2965.
7. Qiang Lin#, Hua-Yan Xie#, Qing Tang#, Hai-Shan Zhang, Min-Jing Cheng, Zhao-Chun Zhan, Hong-Xiao Wang, Yao-Lan Li, Hao Wang*, Guo-Cai Wang*, Yu-Bo Zhang*. Garcioblons A-F, polycyclic polyprenylated acylphloroglucinolswith diverse rearranged skeletons fromGarcinia oblongifolia. Organic Letters, 2025, 27(13), 3273-3278.
8. Zhong-Nan Wu#, Neng-Hua Chen#, Qing Tang, Si Chen, Zhao-Chun Zhan, Yu-Bo Zhang,* Guo-Cai Wang,* Yao-Lan Li,* Wen-Cai Ye. β-Carboline alkaloids from the seeds of Peganum harmala and their anti-HSV-2 virus activities. Organic Letters, 2020, 22(18), 7310-7314.
9. Jin-Xuan Su, Hai-Xia Zhou, Zhi-Jing Zhang, Xiao-Feng Zhou, Qiu-Ming Zou, Si-Jia Li, Xiao-Song Zhuang, Jian-Qin Lai, Si-Yu Yang, Kai Cui, Yong-Qi Liu, Rui-Jie Yuan, Heng-Xin Pan, Zi-Sheng Li,Han-Yun Tu, Mei Cheng*, Yu Yan*, Qi Qi*, Yu-Bo Zhang*. Gracillin suppresses cancer progression through inducing Merlin/LATS protein-protein interaction and activating Hippo signaling pathway. Acta Pharmacologica Sinica, 2025, 46, 2016-2028.
10. Ding Luo,# Xiao-Yong Dai,# He Tian,# Chun-Lin Fan,* Hua-Yan Xie, Neng-Hua Chen, Jing-Hao Wang, Lai-Qiang Huang, Hao Wang,* Guo-Cai Wang,* Yu-Bo Zhang*. Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis and autophagy.Phytomedicine, 2023, 116: 154909.
11. Jing Li,# Xi Shen,# Chun-Hui Sun,# Yi-Bo Hou, Ya Hu, Shao-Hua Ma, Lai-Qiang Huang, Lan Ma*, Yu-Bo Zhang*, Xiao-Yong Dai*. Isogarcinol inhibits nasopharyngeal carcinoma growth through mitochondria-mediated autophagic cell death. Phytomedicine, 2024, 130: 155745.
12. Zhong-Nan Wu,#Xiao-Yong Dai,# Wen-Zhi Wang,# Xian-Fang Zhang, Jia-Wei Chen, Jing Liu, Lai-Qiang Huang, Yao-Lan Li, Shui-Xing Zhang,* Guo-Cai Wang,* Yu-Bo Zhang*. Polyprenylated benzophenones and tocotrienol derivatives from the edible fruits of Garcinia oblongifolia Champ. ex Benth. and their cytotoxicity activity. Journal of Agricultural and Food Chemistry 2022, 70(34): 10506–10520.
13. Wen Li,#Zhong-Nan Wu,#Yi-Ping Xia,#Jin-Lin Tan, Hai-Yue Zhao, Si Chen, Yao-Lan Li, Hong-Feng Tang,* Guo-Cai Wang,* Yu-Bo Zhang*. Antiviral and antioxidant components from the fruits of Illiciumverum Hook.f. (Chinese star anise). Journal of Agricultural and Food Chemistry, 2022, 70(12): 3697-3707.
14. Guo-Qiang Li#, Yu-Bo Zhang#, Peng Wu#, Neng-Hua Chen, Zhong-Nan Wu, Li Yang, Rui-Xia Qiu, Guo-Cai Wang,* Yao-Lan Li*. New phloroglucinol derivatives from the fruit tree Syzygium jambos and their cytotoxic and antioxidant activities. Journal of Agricultural and Food Chemistry, 2015, 63(47), 10257-10262.
15. Qing Tang#, Xiao-Yong Dai#, Zhao-Chun Zhan#, Yi-Kun Hao, Jin-Lin Tan, Hai-Yue Zhao, Yibo Hou, Wen-Sheng Xuan, Yao-lan Li, Lai-Qiang Huang*, Guo-Cai Wang*, Yu-Bo Zhang*. Triterpenoids from the leaves of Synsepalum dulcificum and their antitumor activities against hepatocellular carcinoma cells. Industrial Crops and Products, 2023, 193: 116155.
16. Neng-Hua Chen#, Wen Li#, Ji-Hui Zhang, Wei-Bin Xu, Zhong-Nan Wu, Yao-Lan Li, Yu-Bo Zhang*, Qing-Wen Zhang*, Guo-Cai Wang*. Isolation and structural elucidation of β-tocopherol derivatives from Dryopteris crassirhizoma. Industrial Crops and Products, 2021, 172, 114010. .
17.Neng-HuaChen,#Zhong-NanWu,#WenLi,#Ying-YingLi, DingLuo, Li-FengChen, Xiao-LiZhang, Yu-BoZhang,*Guo-CaiWang,*Yao-LanLi*. Acylphloroglucinols-based meroterpenoid enantiomers with antiviral activities from Dryopteris crassirhizoma. Industrial Crops and Products, 2020, 150, 112415.
18.Hai-YueZhao,#Zhao-ChunZhan,#Hui-LinOu,#Tian-YuanWu,Hui-HuiZhu,QiangLin,Yao-LanLi,Jing-HaoWang,Guang-XiongZhou,QingTang,*Yu-BoZhang,*Guo-CaiWang*. Dihydro-β-agarofuran sesquiterpenoids from the root bark of Tripterygium wilfordii and their anti-neuroinflammatory activities. Bioorganic Chemistry, 2025, 157, 108236.
19. Ding Luo, Qiang Lin, Jin-Lin Tan, Hai-Yue Zhao, Xiao Feng, Neng-Hua Chen, Zhong-Nan Wu, Chun-Lin Fan, Yao-Lan Li, Wei-Long Ding, Fei Xiao,* Guo-Cai Wang,*Yu-Bo Zhang*. Water-soluble matrine-type alkaloids with potential anti-neuroinflammatory activities from the seeds of Sophora alopecuroides. Bioorganic Chemistry, 2021, 116, 105337.
广东省100位博士博士后创新人物，2019
《南方医科大学学报》青年编委
广东省研究型医院学会医学技术转化专业委员会副秘书长
广东省生物医学工程学会药品食品智能制造工程分会委员
