生理学 讲师
职称：讲师
学科专业：生理学
研究方向：肿瘤耐药生理机制研究及靶向药物开发
行政职务：无
电子邮箱：daixy18@jnu.edu.cn
个人介绍：代小勇，清华大学工学博士，暨南大学讲师，硕士生导师，四川省内江市优秀青年人才、海南省三亚市最美科技工作者。主要基于肿瘤类器官研究肿瘤细胞与免疫微环境互作促进耐药的关系，在靶蛋白降解分子、小分子化合物以及多肽药物研发方面具有丰富经验。以第一作者或通讯作者在Advanced Science（2篇）、Journal of Experimental & Clinical Cancer Research（2篇）、EMBO Molecular Medicine、Interdisciplinary Medicine、Phytomedicine（2篇）等期刊共发表30篇SCI文章（中科院1区13篇），H-index 17，申请并授权35项发明专利。主持中国博士后面上项目、广东省面上项目、深圳市面上项目，参与国自然专项项目、国自然面上项目、广东省基础与应用基础联合基金项目等。广东省研究型医院学会医学技术转化专业委员会常务委员。以第一完成人获广东省科技成果转化促进会“科技成果转化奖一等奖”、第二十六届中国国际高新技术成果交易会优秀科研成果创新奖等。担任Frontiers in Cell and Developmental Biology客座编辑、Frontiers in Medicine Review Editor，Organ Medicine和iLiver杂志青年编委，Advanced Science、Acta Pharmacologica Sinica等20个SCI杂志审稿人。
2018.08-2022.10，清华大学，博士，精准医学与公共健康
2011.09-2014.07，暨南大学，硕士，微生物与生化药学
2006.09-2010.07，内蒙古师范大学，本科，生物技术
工作经历
2024.12-至今，暨南大学基础医学与公共卫生学院，讲师
2022.11-2024.11，清华大学深圳国际研究生院，博士后
2016.08-2018.08，中国科学院深圳先进技术研究院，助理研究员
1. Hengyuan Gao#, Junqing Lin#, Xiaobing Chen#, Yingshi Su, Yibin Huang, Yubo Zhang, Junchang Zhang*, Nan Xu*, Xiaoyong Dai*. Microfluidic-based patient-derived organoids recapitulate thyroid cancer heterogeneity and reveal NF-κB-driven maturation for precision therapy. Journal of TranslationalMedicine. 2026 Feb 27.
2. Albert Yu#, Yibo Hou#, Kaibin Huang#, Xucan Gao, Rong Zeng, Chaowei Zhu, Chunhui Sun, Guocai Wang, Lei Ye, Shaohua Ma, Tian Meng*, Bing Guo*, Yubo Zhang*, Xiaoyong Dai*. Anti-CD47 antibody-decorated and Cisplatin-containing mesoporous silica nanoparticles for targeted chemoimmunotherapy of colorectal cancer in a patient-derived organoids xenograft model. Interdisciplinary Medicine. 2026 Jan;4(1):e70075.
3. Jiaqi Wang#, Xiangsai Li#, George Michael Nicolas#, Yongde Cai#, Tianying Yuan, Xiu Yan,4 Jin Wang, Chuqian Ruan, Zitian Wang, Weijie Zhang*, Xiaoyong Dai*, Shaohua Ma*, Xudong Chen*. Programmable viscoelastic hydrogels exhibitantimicrobial and regenerative properties topromote cell migration, wound healing, andtissue remodeling. Microsystems & Nanoengineering. 2026 Feb.
4. Yibo Hou#, Zixian Wang#, Wenlin Wang#, Qing Tang, Yongde Cai, Siyang Yu, Jin Wang, Xiu Yan, Guocai Wang, Peter E Lobie, Yubo Zhang*, Xiaoyong Dai*, Shaohua Ma*. AI-identified CD133-targeting natural compounds demonstrate differential anti-tumor effects and mechanisms in pan-cancer models.EMBO Molecular Medicine.2025 Nov;17(11):2932-2965.
5. Siyu Yang#, Huayan Xie#, Qiang Lin#, Liujin Zhou, Junxi Liu, Zekai Fang, Ziling Tang, Ruijie Yuan, Jinxuan Su, Sijia Li, Wenlin Wang, Mingyu Pan, Hao Wang*, Xiaoyong Dai*, Guocai Wang*, Yubo Zhang*. EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non-Small Cell Lung Cancer via Hippo Pathway Activation. Advanced Science. 2025Oct 27:e10508.
6. Jiaye Mo, Da Gong, Mei Zhai, Jintao Yang, Zhike Li, Meilong Wu*, Xuesong Deng*, Xiaoyong Dai*. The application of liver cancer organoids in tumour precision medicine: A comprehensive review. iLiver. 2025 Jul;4(3):100179.
7. Jing Li#, Xi Shen#, Chunhui Sun#, Yibo Hou, Ya Hu, Shaohua Ma, Laiqiang Huang, Lan Ma*, Yubo Zhang*, Xiaoyong Dai*. Isogarcinol inhibits nasopharyngeal carcinoma growth through mitochondria-mediated autophagic cell death. Phytomedicine. 2024 Jul 25:130:155745.
8. Chunyan Feng, Albert Yu, Kun Wang, Jiawei Chen, Yaojiong Wu, Ting Deng, Huaqing Chen, Yibo Hou, Xiaoyong Dai*, Laiqiang Huang*. A novel PDPN antagonist peptide CY12-RP2 inhibits melanoma growth via Wnt/β-catenin and modulates the immune cells. JournalofExperimental&ClinicalCancerResearch.2024 Jan 2;43(1):9.
9. Zhongnan Wu, Wen Li, Qing Tang, Laiqiang Huang, Zhaochun Zhan, Yaolan Li, Guocai Wang, Xiaoyong Dai*, Yubo Zhang*. A Novel Aniline Derivative fromPeganum harmalaL. Promoted Apoptosis via Activating PI3K/AKT/mTOR-Mediated Autophagy in Non-Small Cell Lung Cancer Cells. International Journal Molecular Sciences. 2023 Aug 10;24(16):12626.
10. Ting Deng, Yibo Hou, Gaoyang Lin, Chunyan Feng, Kewei Liu, Wenke Chen, Wei Wei, Laiqiang Huang*, Xiaoyong Dai*.A novel Fibromodulin antagonist peptide RP4 exerts antitumor effects on colorectal cancer. Pharmaceutics. 2023 Mar 14;15(3):944.
11. Yibo Hou, Jianing Li, Albert Yu, Kexin Deng, Jiawei Chen, Zixian Wang, Laiqiang Huang*, Shaohua Ma*, Xiaoyong Dai*. FANCI is Associated with Poor Prognosis and Immune Infiltration in Liver Hepatocellular Carcinoma. International Journal of Medical Sciences. 2023 May 12;20(7):918-932.
12. Kun Wang, Albert Yu, Kewei Liu, Chunyan Feng, Yibo Hou, Jiawei Chen, Shaohua Ma*, Laiqiang Huang*, Xiaoyong Dai*.Nano-LYTACs for Degradation of Membrane Proteins and Inhibition of CD24/Siglec-10 Signaling Pathway. Advanced Science. 2023 Mar 3:e2300288.
13. Qing Tang#, Xiao-Yong Dai#, Qiang Lin#, Zhi-Peng Ling, Yi-Kun Hao, Tian-Xi Zhu, Ji-Hui Zhang, Yi-Bo Hou, Yao-Lan Li, Lai-Qiang Huang, Jing-Hao Wang*, Guo-Cai Wang*, Yu-Bo Zhang*. Dcalycinumines A–E, alkaloids with cytotoxic activities of nasopharyngeal carcinoma cells fromDaphniphyllum calycinum. Chinese Journalof Chemistry. 2023Oct.
14. Xiaoyong Dai, Yibo Hou, Ting Deng, Gaoyang Lin, Yuanxiong Cao, Guiyuan Yu, Wei Wei, Qing Zheng, Laiqiang Huang*, Shaohua Ma*. A specific RAGE-binding peptide inhibits triple negative breast cancer growth through blocking of Erk1/2/NF-κB pathway. European Journal of Pharmacology. 2023 Jun26;954:175861.
15. Ding Luo#, Xiaoyong Dai#, He Tian, Chunlin Fan, Huayan Xie, Nenghua Chen, Jinhao Wang, Laiqiang Huang, Hao Wang*, Guocai Wang*, Yubo Zhang*. Sophflarine A, a novel matrine-derived 1 alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis and autophagy. Phytomedicine. 2023 May 29.
16. Dongdong Guo#, Xiaoyong Dai#, Kewei Liu, Yuhong Liu, Jiamin Wu, Kun Wang, Shengwei Jiang, Fen Sun, Lijun Wang, Bin Guo*, Dongye Yang*, Laiqiang Huang*. A Self-Reinforcing Nanoplatform for Highly Effective Synergistic Targeted Combinatary Calcium-Overload and Photodynamic Therapy of Cancer. Advanced Healthcare Materials.2023 Jan 24.
17. Qing Tang#, Xiaoyong Dai#, Zhaochun Zhan#, Yikun Hao, Jinlin Tan, Haiyue Zhao, Yibo Hou, Wensheng Xuan, Yaolan Li , Laiqiang Huang*, Guocai Wang*, Yubo Zhang*. Triterpenoids from the leaves of Synsepalum dulcificum and their antitumor activities against hepatocellular carcinoma cells. Industrial Crops and Products. 2022 Dec 193;0926-6690:116155.
18. Kun Wang#, Xiaoyong Dai#, Albert Yu, Chunyan Feng, Kewei Liu, Laiqiang Huang*. Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression. Journalof Experimental & Clinical Cancer Research. 2022 Sep 29;41(1):289.
19. Zhongnan Wu#, Xiaoyong Dai#, Wenzhi Wang#, Xianfang Zhang, Jiawei Chen, Jing Liu, Laiqiang Huang, Yaolan Li, Shuixing Zhang*, Guocai Wang*, Yubo Zhang*. Polyprenylated Benzophenones and Tocotrienol Derivatives from the Edible Fruits of Garcinia oblongifolia Champ. ex Benth. and Their Cytotoxicity Activity. Journalof Agriculturaland Food Chemistry. 2022 Aug 23.
1. 《诺贝尔奖解析-医学篇》，副主编。
1. 广东省科技成果转化促进会科技成果转化奖一等奖，2025
2. 第二十六届中国国际高新技术成果交易会优秀科研成果创新奖，2024
3. 第二十五届中国国际高新技术成果交易会优秀产品奖，2023
4. 第八届清华校友三创大赛健康医疗全球总决赛十强奖，2023
1. 广东省医学技术转化专业委员会常务委员
2. Organ medicine杂志青年编委
3. Advanced Science、SCIENCE CHINA Life Sciences等20余个SCI杂志审稿人
